Matches in SemOpenAlex for { <https://semopenalex.org/work/W2966283991> ?p ?o ?g. }
- W2966283991 endingPage "617" @default.
- W2966283991 startingPage "610" @default.
- W2966283991 abstract "Foot-and-mouth disease virus (FMDV) can infect domestic and wild cloven-hoofed animals. The non-structural protein 3D plays an important role in FMDV replication and pathogenesis. However, the interaction partners of 3D, and the effects of those interactions on FMDV replication, remain incompletely elucidated. In the present study, using the yeast two-hybrid system, we identified a porcine cell protein, DEAD-box RNA helicase 1 (DDX1), which interacted with FMDV 3D. The DDX1-3D interaction was further confirmed by co-immunoprecipitation experiments and an indirect immunofluorescence assay (IFA) in porcine kidney 15 (PK-15) cells. DDX1 was reported to either inhibit or facilitate viral replication and regulate host innate immune responses. However, the roles of DDX1 during FMDV infection remain unclear. Our results revealed that DDX1 inhibited FMDV replication in an ATPase/helicase activity-dependent manner. In addition, DDX1 stimulated IFN-β activation in FMDV-infected cells. Together, our results expand the body of knowledge regarding the role of DDX1 in FMDV infection." @default.
- W2966283991 created "2019-08-13" @default.
- W2966283991 creator A5001799309 @default.
- W2966283991 creator A5010308883 @default.
- W2966283991 creator A5024371948 @default.
- W2966283991 creator A5044010361 @default.
- W2966283991 creator A5065765548 @default.
- W2966283991 creator A5075929234 @default.
- W2966283991 date "2019-07-29" @default.
- W2966283991 modified "2023-10-16" @default.
- W2966283991 title "The DEAD-Box RNA Helicase DDX1 Interacts with the Viral Protein 3D and Inhibits Foot-and-Mouth Disease Virus Replication" @default.
- W2966283991 cites W1521357048 @default.
- W2966283991 cites W1982831502 @default.
- W2966283991 cites W1993374643 @default.
- W2966283991 cites W1997148905 @default.
- W2966283991 cites W1998635195 @default.
- W2966283991 cites W2006784855 @default.
- W2966283991 cites W2021481489 @default.
- W2966283991 cites W2028468676 @default.
- W2966283991 cites W2030512217 @default.
- W2966283991 cites W2032639971 @default.
- W2966283991 cites W2037691295 @default.
- W2966283991 cites W2058210634 @default.
- W2966283991 cites W2063125566 @default.
- W2966283991 cites W2099420679 @default.
- W2966283991 cites W2103738533 @default.
- W2966283991 cites W2114570899 @default.
- W2966283991 cites W2122755078 @default.
- W2966283991 cites W2158728603 @default.
- W2966283991 cites W2220028451 @default.
- W2966283991 cites W2279656743 @default.
- W2966283991 cites W2319882022 @default.
- W2966283991 cites W2404439056 @default.
- W2966283991 cites W2471537492 @default.
- W2966283991 cites W2513328804 @default.
- W2966283991 cites W2529320990 @default.
- W2966283991 cites W2563716669 @default.
- W2966283991 cites W2576819271 @default.
- W2966283991 cites W2585536752 @default.
- W2966283991 cites W2615924632 @default.
- W2966283991 cites W2626336399 @default.
- W2966283991 cites W2641756084 @default.
- W2966283991 cites W2741804374 @default.
- W2966283991 cites W2765333351 @default.
- W2966283991 cites W2793183654 @default.
- W2966283991 cites W2795369286 @default.
- W2966283991 cites W2808312037 @default.
- W2966283991 cites W2811320761 @default.
- W2966283991 doi "https://doi.org/10.1007/s12250-019-00148-7" @default.
- W2966283991 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6888807" @default.
- W2966283991 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31359346" @default.
- W2966283991 hasPublicationYear "2019" @default.
- W2966283991 type Work @default.
- W2966283991 sameAs 2966283991 @default.
- W2966283991 citedByCount "21" @default.
- W2966283991 countsByYear W29662839912020 @default.
- W2966283991 countsByYear W29662839912021 @default.
- W2966283991 countsByYear W29662839912022 @default.
- W2966283991 countsByYear W29662839912023 @default.
- W2966283991 crossrefType "journal-article" @default.
- W2966283991 hasAuthorship W2966283991A5001799309 @default.
- W2966283991 hasAuthorship W2966283991A5010308883 @default.
- W2966283991 hasAuthorship W2966283991A5024371948 @default.
- W2966283991 hasAuthorship W2966283991A5044010361 @default.
- W2966283991 hasAuthorship W2966283991A5065765548 @default.
- W2966283991 hasAuthorship W2966283991A5075929234 @default.
- W2966283991 hasBestOaLocation W29662839911 @default.
- W2966283991 hasConcept C104317684 @default.
- W2966283991 hasConcept C136449434 @default.
- W2966283991 hasConcept C140704245 @default.
- W2966283991 hasConcept C159047783 @default.
- W2966283991 hasConcept C161223559 @default.
- W2966283991 hasConcept C2522874641 @default.
- W2966283991 hasConcept C2776151397 @default.
- W2966283991 hasConcept C2779568538 @default.
- W2966283991 hasConcept C2780879997 @default.
- W2966283991 hasConcept C54355233 @default.
- W2966283991 hasConcept C67705224 @default.
- W2966283991 hasConcept C68592252 @default.
- W2966283991 hasConcept C86803240 @default.
- W2966283991 hasConcept C8891405 @default.
- W2966283991 hasConcept C95444343 @default.
- W2966283991 hasConceptScore W2966283991C104317684 @default.
- W2966283991 hasConceptScore W2966283991C136449434 @default.
- W2966283991 hasConceptScore W2966283991C140704245 @default.
- W2966283991 hasConceptScore W2966283991C159047783 @default.
- W2966283991 hasConceptScore W2966283991C161223559 @default.
- W2966283991 hasConceptScore W2966283991C2522874641 @default.
- W2966283991 hasConceptScore W2966283991C2776151397 @default.
- W2966283991 hasConceptScore W2966283991C2779568538 @default.
- W2966283991 hasConceptScore W2966283991C2780879997 @default.
- W2966283991 hasConceptScore W2966283991C54355233 @default.
- W2966283991 hasConceptScore W2966283991C67705224 @default.
- W2966283991 hasConceptScore W2966283991C68592252 @default.
- W2966283991 hasConceptScore W2966283991C86803240 @default.
- W2966283991 hasConceptScore W2966283991C8891405 @default.
- W2966283991 hasConceptScore W2966283991C95444343 @default.
- W2966283991 hasIssue "6" @default.