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• W2966302431 endingPage "3704" @default.
• W2966302431 startingPage "3704" @default.
• W2966302431 abstract "Mouse hind limb ischemia is the most common used preclinical model for peripheral arterial disease and critical limb ischemia. This model is used to investigate the mechanisms of neovascularization and to develop new therapeutic agents. The literature shows many variations in the model, including the method of occlusion, the number of occlusions, and the position at which the occlusions are made to induce hind limb ischemia. Furthermore, predefined end points and the histopathological and radiological analysis vary. These differences hamper the correlation of results between different studies. In this review, variations in surgical methods of inducing hind limb ischemia in mice are described, and the consequences of these variations on perfusion restoration and vascular remodeling are discussed. This study aims at providing the reader with a comprehensive overview of the methods so far described, and proposing uniformity in research of hind limb ischemia in a mouse model." @default.
• W2966302431 created "2019-08-13" @default.
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• W2966302431 date "2019-07-29" @default.
• W2966302431 modified "2023-10-14" @default.
• W2966302431 title "Variations in Surgical Procedures for Inducing Hind Limb Ischemia in Mice and the Impact of These Variations on Neovascularization Assessment" @default.
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• W2966302431 doi "https://doi.org/10.3390/ijms20153704" @default.
• W2966302431 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6696155" @default.
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• W2966302431 hasPublicationYear "2019" @default.
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