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• W2966332834 startingPage "1563" @default.
• W2966332834 abstract "Introduction: Lennox-Gastaut syndrome (LGS) is a chronic, epileptic encephalopathy, characterized by multiple seizure types, distinctive slow spike-wave patterns in the electroencephalogram (EEG), and severe cognitive and behavioral comorbidities. Seizures are typically refractory and long-term prognosis is poor. No antiseizure drug (ASD) is fully effective as a monotherapy. Clobazam (CLB) was licensed in the United States in 2011 as an adjunctive therapy for seizures in LGS. In 2018, a new formulation, CLB oral soluble film (COSF) (AQST-120), was approved by the Federal Drug Administration (FDA) for the same indication.Areas covered: The authors summarize current pharmacological options and guidelines for the management of seizures in LGS and efficacy and safety findings from phase II and III randomized controlled trials of adjunctive CLB in patients with LGS. An open-label extension trial is also considered. A pharmacokinetic comparison of COSF and CLB tablets is also undertaken.Expert opinion: CLB is partly effective as an add-on therapy in treating seizures in LGS. Adverse effects, pharmacokinetic interactions and the potential for tolerance with long-term treatment should be weighed against the clinical benefit when considering the introduction of CLB in this population. COSF has a similar pharmacokinetic profile to CLB tablets and may help to improve adherence to treatment." @default.
• W2966332834 created "2019-08-13" @default.
• W2966332834 creator A5018555892 @default.
• W2966332834 creator A5040670651 @default.
• W2966332834 date "2019-08-02" @default.
• W2966332834 modified "2023-10-16" @default.
• W2966332834 title "An evaluation of clobazam tablets and film (AQST-120) for the treatment of Lennox-Gastaut syndrome" @default.
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• W2966332834 doi "https://doi.org/10.1080/14656566.2019.1642872" @default.
• W2966332834 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31373526" @default.
• W2966332834 hasPublicationYear "2019" @default.
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