Matches in SemOpenAlex for { <https://semopenalex.org/work/W2966437364> ?p ?o ?g. }
Showing items 1 to 84 of
84
with 100 items per page.
- W2966437364 endingPage "387" @default.
- W2966437364 startingPage "378" @default.
- W2966437364 abstract "Risankizumab has demonstrated efficacy in phase III trials in patients with moderate-to-severe plaque psoriasis. The exposure-response relationships for risankizumab efficacy (Psoriasis Area and Severity Index (PASI)75, PASI90, PASI100, and static Physician's Global Assessment (sPGA)0/1) at week 16 (N = 1,732) and week 52 (N = 598) as well as safety (incidence of any adverse event, serious adverse event, infection and infestation, or serious infection) over up to 52 weeks were characterized using the data from risankizumab phase II and III clinical trials in patients with moderate-to-severe plaque psoriasis. Impact of clinically relevant covariates was evaluated. Risankizumab phase III regimen (150 mg subcutaneously at weeks 0, 4, and every 12 weeks thereafter) achieved the plateau of the exposure-efficacy relationships with model-estimated PASI90 and sPGA0/1 response probabilities of 77%, and 87%, respectively, at week 16 and 85%, and 88%, respectively, at week 52. There was no apparent relationship between risankizumab plasma exposure and the evaluated safety variables." @default.
- W2966437364 created "2019-08-13" @default.
- W2966437364 creator A5021168706 @default.
- W2966437364 creator A5038665116 @default.
- W2966437364 creator A5055080058 @default.
- W2966437364 creator A5087312068 @default.
- W2966437364 date "2019-09-26" @default.
- W2966437364 modified "2023-10-18" @default.
- W2966437364 title "Exposure–Response Relationships for Efficacy and Safety of Risankizumab in Phase II and III Trials in Psoriasis Patients" @default.
- W2966437364 cites W2117897510 @default.
- W2966437364 cites W2606035821 @default.
- W2966437364 cites W2623888527 @default.
- W2966437364 cites W2786492839 @default.
- W2966437364 cites W2887412253 @default.
- W2966437364 cites W2900015706 @default.
- W2966437364 cites W2901276593 @default.
- W2966437364 cites W2943637544 @default.
- W2966437364 cites W4211077900 @default.
- W2966437364 cites W4211176133 @default.
- W2966437364 doi "https://doi.org/10.1002/cpt.1594" @default.
- W2966437364 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7006881" @default.
- W2966437364 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31355921" @default.
- W2966437364 hasPublicationYear "2019" @default.
- W2966437364 type Work @default.
- W2966437364 sameAs 2966437364 @default.
- W2966437364 citedByCount "11" @default.
- W2966437364 countsByYear W29664373642019 @default.
- W2966437364 countsByYear W29664373642020 @default.
- W2966437364 countsByYear W29664373642021 @default.
- W2966437364 countsByYear W29664373642022 @default.
- W2966437364 crossrefType "journal-article" @default.
- W2966437364 hasAuthorship W2966437364A5021168706 @default.
- W2966437364 hasAuthorship W2966437364A5038665116 @default.
- W2966437364 hasAuthorship W2966437364A5055080058 @default.
- W2966437364 hasAuthorship W2966437364A5087312068 @default.
- W2966437364 hasBestOaLocation W29664373641 @default.
- W2966437364 hasConcept C120665830 @default.
- W2966437364 hasConcept C121332964 @default.
- W2966437364 hasConcept C126322002 @default.
- W2966437364 hasConcept C16005928 @default.
- W2966437364 hasConcept C197934379 @default.
- W2966437364 hasConcept C2777011040 @default.
- W2966437364 hasConcept C2780564577 @default.
- W2966437364 hasConcept C2781413609 @default.
- W2966437364 hasConcept C535046627 @default.
- W2966437364 hasConcept C61511704 @default.
- W2966437364 hasConcept C71924100 @default.
- W2966437364 hasConcept C90924648 @default.
- W2966437364 hasConceptScore W2966437364C120665830 @default.
- W2966437364 hasConceptScore W2966437364C121332964 @default.
- W2966437364 hasConceptScore W2966437364C126322002 @default.
- W2966437364 hasConceptScore W2966437364C16005928 @default.
- W2966437364 hasConceptScore W2966437364C197934379 @default.
- W2966437364 hasConceptScore W2966437364C2777011040 @default.
- W2966437364 hasConceptScore W2966437364C2780564577 @default.
- W2966437364 hasConceptScore W2966437364C2781413609 @default.
- W2966437364 hasConceptScore W2966437364C535046627 @default.
- W2966437364 hasConceptScore W2966437364C61511704 @default.
- W2966437364 hasConceptScore W2966437364C71924100 @default.
- W2966437364 hasConceptScore W2966437364C90924648 @default.
- W2966437364 hasIssue "2" @default.
- W2966437364 hasLocation W29664373641 @default.
- W2966437364 hasLocation W29664373642 @default.
- W2966437364 hasLocation W29664373643 @default.
- W2966437364 hasLocation W29664373644 @default.
- W2966437364 hasOpenAccess W2966437364 @default.
- W2966437364 hasPrimaryLocation W29664373641 @default.
- W2966437364 hasRelatedWork W1969368658 @default.
- W2966437364 hasRelatedWork W1998836331 @default.
- W2966437364 hasRelatedWork W2342481736 @default.
- W2966437364 hasRelatedWork W2898213950 @default.
- W2966437364 hasRelatedWork W2901045010 @default.
- W2966437364 hasRelatedWork W2963043097 @default.
- W2966437364 hasRelatedWork W2977368346 @default.
- W2966437364 hasRelatedWork W3022724713 @default.
- W2966437364 hasRelatedWork W3127787045 @default.
- W2966437364 hasRelatedWork W3176363967 @default.
- W2966437364 hasVolume "107" @default.
- W2966437364 isParatext "false" @default.
- W2966437364 isRetracted "false" @default.
- W2966437364 magId "2966437364" @default.
- W2966437364 workType "article" @default.