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- W2966604335 abstract "Representative in vitro models that mimic the native bone tumor microenvironment are warranted to support the development of more successful treatments for bone metastases. Here, we have developed a primary cell 3D model consisting of a human osteoblast-derived tissue-engineered construct (hOTEC) indirectly co-cultured with patient-derived prostate cancer xenografts (PDXs), in order to study molecular interactions in a patient-derived microenvironment context. The engineered biomimetic microenvironment had high mineralization and embedded osteocytes, and supported a high degree of cancer cell osteomimicry at the gene, protein and mineralization levels when co-cultured with prostate cancer PDXs from a lymph node metastasis (LuCaP35) and bone metastasis (BM18) from patients with primary prostate cancer. This fully patient-derived model is a promising tool for the assessment of new molecular mechanisms and as a personalized pre-clinical platform for therapy testing for patients with prostate cancer bone metastases." @default.
- W2966604335 created "2019-08-13" @default.
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- W2966604335 date "2019-11-01" @default.
- W2966604335 modified "2023-10-03" @default.
- W2966604335 title "Microenvironment engineering of osteoblastic bone metastases reveals osteomimicry of patient-derived prostate cancer xenografts" @default.
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- W2966604335 doi "https://doi.org/10.1016/j.biomaterials.2019.119402" @default.
- W2966604335 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31400612" @default.
- W2966604335 hasPublicationYear "2019" @default.
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