Matches in SemOpenAlex for { <https://semopenalex.org/work/W2966629959> ?p ?o ?g. }
- W2966629959 endingPage "538" @default.
- W2966629959 startingPage "527" @default.
- W2966629959 abstract "Objective To investigate whether functional sweet spots of deep brain stimulation (DBS) in the subthalamic nucleus (STN) can predict motor improvement in Parkinson disease (PD) patients. Methods Stimulation effects of 449 DBS settings in 21 PD patients were clinically and quantitatively assessed through standardized monopolar reviews and mapped into standard space. A sweet spot for best motor outcome was determined using voxelwise and nonparametric permutation statistics. Two independent cohorts were used to investigate whether stimulation overlap with the sweet spot could predict acute motor outcome (10 patients, 163 settings) and long‐term overall Unified Parkinson's Disease Rating Scale Part III (UPDRS‐III) improvement (63 patients). Results Significant clusters for suppression of rigidity and akinesia, as well as for overall motor improvement, resided around the dorsolateral border of the STN. Overlap of the volume of tissue activated with the sweet spot for overall motor improvement explained R 2 = 37% of the variance in acute motor improvement, more than triple what was explained by overlap with the STN ( R 2 = 9%) and its sensorimotor subpart ( R 2 = 10%). In the second independent cohort, sweet spot overlap explained R 2 = 20% of the variance in long‐term UPDRS‐III improvement, which was equivalent to the variance explained by overlap with the STN ( R 2 = 21%) and sensorimotor STN ( R 2 = 19%). Interpretation This study is the first to predict clinical improvement of parkinsonian motor symptoms across cohorts based on local DBS effects only. The new approach revealed a distinct sweet spot for STN DBS in PD. Stimulation overlap with the sweet spot can predict short‐ and long‐term motor outcome and may be used to guide DBS programming. ANN NEUROL 2019;86:527–538" @default.
- W2966629959 created "2019-08-13" @default.
- W2966629959 creator A5002340019 @default.
- W2966629959 creator A5005468329 @default.
- W2966629959 creator A5006315449 @default.
- W2966629959 creator A5014143080 @default.
- W2966629959 creator A5022205724 @default.
- W2966629959 creator A5034379711 @default.
- W2966629959 creator A5043378465 @default.
- W2966629959 creator A5053964142 @default.
- W2966629959 creator A5054591613 @default.
- W2966629959 creator A5060370127 @default.
- W2966629959 creator A5079864110 @default.
- W2966629959 creator A5082254809 @default.
- W2966629959 date "2019-09-14" @default.
- W2966629959 modified "2023-10-11" @default.
- W2966629959 title "Probabilistic sweet spots predict motor outcome for deep brain stimulation in Parkinson disease" @default.
- W2966629959 cites W1880431790 @default.
- W2966629959 cites W1964722702 @default.
- W2966629959 cites W1970928383 @default.
- W2966629959 cites W1992115624 @default.
- W2966629959 cites W1998096139 @default.
- W2966629959 cites W2015739774 @default.
- W2966629959 cites W2019020119 @default.
- W2966629959 cites W2020745232 @default.
- W2966629959 cites W2023721345 @default.
- W2966629959 cites W2025162361 @default.
- W2966629959 cites W2025955039 @default.
- W2966629959 cites W2026350701 @default.
- W2966629959 cites W2033621157 @default.
- W2966629959 cites W2045695716 @default.
- W2966629959 cites W2048689682 @default.
- W2966629959 cites W2061588984 @default.
- W2966629959 cites W2063152280 @default.
- W2966629959 cites W2084910998 @default.
- W2966629959 cites W2093909939 @default.
- W2966629959 cites W2111624468 @default.
- W2966629959 cites W2118100625 @default.
- W2966629959 cites W2125240117 @default.
- W2966629959 cites W2126000859 @default.
- W2966629959 cites W2139526581 @default.
- W2966629959 cites W2144639273 @default.
- W2966629959 cites W2155931363 @default.
- W2966629959 cites W2158196600 @default.
- W2966629959 cites W2168860829 @default.
- W2966629959 cites W2255627108 @default.
- W2966629959 cites W2468867754 @default.
- W2966629959 cites W2545430681 @default.
- W2966629959 cites W2553685526 @default.
- W2966629959 cites W2557047195 @default.
- W2966629959 cites W2578397323 @default.
- W2966629959 cites W2582022757 @default.
- W2966629959 cites W2583340629 @default.
- W2966629959 cites W2609087776 @default.
- W2966629959 cites W2622109244 @default.
- W2966629959 cites W2715301544 @default.
- W2966629959 cites W2734990562 @default.
- W2966629959 cites W2750141215 @default.
- W2966629959 cites W2763229272 @default.
- W2966629959 cites W2775643054 @default.
- W2966629959 cites W2784782899 @default.
- W2966629959 cites W2921745261 @default.
- W2966629959 cites W2950023299 @default.
- W2966629959 cites W2951733616 @default.
- W2966629959 cites W2953279379 @default.
- W2966629959 cites W837240019 @default.
- W2966629959 doi "https://doi.org/10.1002/ana.25567" @default.
- W2966629959 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31376171" @default.
- W2966629959 hasPublicationYear "2019" @default.
- W2966629959 type Work @default.
- W2966629959 sameAs 2966629959 @default.
- W2966629959 citedByCount "112" @default.
- W2966629959 countsByYear W29666299592020 @default.
- W2966629959 countsByYear W29666299592021 @default.
- W2966629959 countsByYear W29666299592022 @default.
- W2966629959 countsByYear W29666299592023 @default.
- W2966629959 crossrefType "journal-article" @default.
- W2966629959 hasAuthorship W2966629959A5002340019 @default.
- W2966629959 hasAuthorship W2966629959A5005468329 @default.
- W2966629959 hasAuthorship W2966629959A5006315449 @default.
- W2966629959 hasAuthorship W2966629959A5014143080 @default.
- W2966629959 hasAuthorship W2966629959A5022205724 @default.
- W2966629959 hasAuthorship W2966629959A5034379711 @default.
- W2966629959 hasAuthorship W2966629959A5043378465 @default.
- W2966629959 hasAuthorship W2966629959A5053964142 @default.
- W2966629959 hasAuthorship W2966629959A5054591613 @default.
- W2966629959 hasAuthorship W2966629959A5060370127 @default.
- W2966629959 hasAuthorship W2966629959A5079864110 @default.
- W2966629959 hasAuthorship W2966629959A5082254809 @default.
- W2966629959 hasBestOaLocation W29666299591 @default.
- W2966629959 hasConcept C126322002 @default.
- W2966629959 hasConcept C138496976 @default.
- W2966629959 hasConcept C15744967 @default.
- W2966629959 hasConcept C169760540 @default.
- W2966629959 hasConcept C1862650 @default.
- W2966629959 hasConcept C2775880387 @default.
- W2966629959 hasConcept C2777319143 @default.
- W2966629959 hasConcept C2778261627 @default.