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• W2966648956 abstract "Abstract Brain lesion and stimulation studies have suggested posterior parietal cortex and the medial intraparietal sulcus in particular as a crucial hub for online movement error corrections. However, causal evidence for this is still sparse. Indeed, lesion studies are potentially confounded by compensatory reorganization mechanisms while brain stimulation studies have produced heterogeneous results when employing transcranial magnetic stimulation. Here we designed a new complementary paradigm using fMRI-guided high-definition transcranial direct current stimulation (HD-tDCS) of the left medial intraparietal sulcus (mIPS) together with regression-based mediation analysis to re-examine the causal role of mIPS in online reach corrections to jumping targets. We obtained two independent measures of stimulation-induced changes in brain activity by modeling current flow in the brain and through EEG recordings before and after HD-tDCS stimulation. Third, to quantify behavioral effects of HD-tDCS we computed movement curvature as a measure of online correction. We demonstrate that both of our measurements of brain activity were consistent with a polarity-specific modulation of the online correction for targets jumping to the contralateral side of the stimulation. Importantly, using a mediation analysis of the relationship between stimulation current and movement curvature suggests that the induced current modifies brain activity, which then leads to the observed behavioral changes. This unique combination of methods and analysis thus provides complementary evidence for the crucial role of the posterior parietal cortex in online error correction, while at the same time setting a new methodological standard with respect to the causal influence of transcranial direct current stimulation. New & Noteworthy Transcranial direct current stimulation (tDCS) is an interesting and potentially useful tool for asking causal scientific questions and design clinical treatments. With our unique combination of highly accurate fMRI guided stimulation, current forward modeling, EEG recordings before and after the stimulation and behavioral changes we could unravel the causal structure of tDCS. Our approach naturally deals with the variability of tDCS results, increasing its potential usefulness as a tool for research and clinical applications." @default.
• W2966648956 created "2019-08-13" @default.
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• W2966648956 date "2019-07-30" @default.
• W2966648956 modified "2023-10-16" @default.
• W2966648956 title "HD-tDCS over mIPS causally modulates online reach correction" @default.
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• W2966648956 doi "https://doi.org/10.1101/708693" @default.
• W2966648956 hasPublicationYear "2019" @default.
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