FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2966718807> ?p ?o ?g. }

• W2966718807 abstract "Abstract The segregation of definitive endoderm (DE) from mesendoderm progenitors leads to the formation of two distinct germ layers. Dissecting DE onset has been challenging as it occurs within a narrow spatio-temporal window in the embryo. Here we employ a dual Bra-GFP, Sox17-RFP reporter cell line to study DE onset dynamics. We find Sox17 starts in a few isolated cells in vivo . Using 2D and 3D in vitro models, we show that DE cells emerge from mesendoderm progenitors at a temporally regular, but spatially stochastic pattern, which is subsequently arranged by self-sorting of Sox17+ cells. Self-sorting coincides with up-regulation of E-cadherin but is not necessary for DE differentiation or proliferation. A subpopulation of Bra-high cells commits to a Sox17+ fate independent of external Wnt signal. Our in vivo and in vitro results highlight basic rules governing DE onset and patterning through the commonalities and differences between these systems." @default.
• W2966718807 created "2019-08-13" @default.
• W2966718807 creator A5010737438 @default.
• W2966718807 creator A5031703305 @default.
• W2966718807 creator A5046952748 @default.
• W2966718807 creator A5072395004 @default.
• W2966718807 creator A5072450044 @default.
• W2966718807 creator A5087454836 @default.
• W2966718807 date "2019-08-07" @default.
• W2966718807 modified "2023-10-16" @default.
• W2966718807 title "Emergence and patterning dynamics of mouse definitive endoderm" @default.
• W2966718807 cites W1925655957 @default.
• W2966718807 cites W1965419330 @default.
• W2966718807 cites W1982748372 @default.
• W2966718807 cites W1998317358 @default.
• W2966718807 cites W2002973634 @default.
• W2966718807 cites W2003267140 @default.
• W2966718807 cites W2009393065 @default.
• W2966718807 cites W2015600085 @default.
• W2966718807 cites W2021593900 @default.
• W2966718807 cites W2027607261 @default.
• W2966718807 cites W2030699054 @default.
• W2966718807 cites W2041573813 @default.
• W2966718807 cites W2063023858 @default.
• W2966718807 cites W2065696902 @default.
• W2966718807 cites W2076812266 @default.
• W2966718807 cites W2083664734 @default.
• W2966718807 cites W2109293927 @default.
• W2966718807 cites W2123604507 @default.
• W2966718807 cites W2139020188 @default.
• W2966718807 cites W2154589460 @default.
• W2966718807 cites W2159747138 @default.
• W2966718807 cites W2166649246 @default.
• W2966718807 cites W2484437811 @default.
• W2966718807 cites W2518250200 @default.
• W2966718807 cites W2535856472 @default.
• W2966718807 cites W2592254692 @default.
• W2966718807 cites W2611685221 @default.
• W2966718807 cites W2760030327 @default.
• W2966718807 cites W2779864458 @default.
• W2966718807 cites W2786431878 @default.
• W2966718807 cites W2800655655 @default.
• W2966718807 cites W2883509033 @default.
• W2966718807 cites W2895161737 @default.
• W2966718807 cites W2903989214 @default.
• W2966718807 cites W2949967751 @default.
• W2966718807 doi "https://doi.org/10.1101/728642" @default.
• W2966718807 hasPublicationYear "2019" @default.
• W2966718807 type Work @default.
• W2966718807 sameAs 2966718807 @default.
• W2966718807 citedByCount "4" @default.
• W2966718807 countsByYear W29667188072020 @default.
• W2966718807 countsByYear W29667188072021 @default.
• W2966718807 countsByYear W29667188072022 @default.
• W2966718807 crossrefType "posted-content" @default.
• W2966718807 hasAuthorship W2966718807A5010737438 @default.
• W2966718807 hasAuthorship W2966718807A5031703305 @default.
• W2966718807 hasAuthorship W2966718807A5046952748 @default.
• W2966718807 hasAuthorship W2966718807A5072395004 @default.
• W2966718807 hasAuthorship W2966718807A5072450044 @default.
• W2966718807 hasAuthorship W2966718807A5087454836 @default.
• W2966718807 hasBestOaLocation W29667188071 @default.
• W2966718807 hasConcept C104317684 @default.
• W2966718807 hasConcept C107459253 @default.
• W2966718807 hasConcept C137620995 @default.
• W2966718807 hasConcept C145103041 @default.
• W2966718807 hasConcept C148738053 @default.
• W2966718807 hasConcept C18155467 @default.
• W2966718807 hasConcept C201750760 @default.
• W2966718807 hasConcept C202751555 @default.
• W2966718807 hasConcept C2777164004 @default.
• W2966718807 hasConcept C2778630268 @default.
• W2966718807 hasConcept C28328180 @default.
• W2966718807 hasConcept C54355233 @default.
• W2966718807 hasConcept C62478195 @default.
• W2966718807 hasConcept C86803240 @default.
• W2966718807 hasConcept C95444343 @default.
• W2966718807 hasConceptScore W2966718807C104317684 @default.
• W2966718807 hasConceptScore W2966718807C107459253 @default.
• W2966718807 hasConceptScore W2966718807C137620995 @default.
• W2966718807 hasConceptScore W2966718807C145103041 @default.
• W2966718807 hasConceptScore W2966718807C148738053 @default.
• W2966718807 hasConceptScore W2966718807C18155467 @default.
• W2966718807 hasConceptScore W2966718807C201750760 @default.
• W2966718807 hasConceptScore W2966718807C202751555 @default.
• W2966718807 hasConceptScore W2966718807C2777164004 @default.
• W2966718807 hasConceptScore W2966718807C2778630268 @default.
• W2966718807 hasConceptScore W2966718807C28328180 @default.
• W2966718807 hasConceptScore W2966718807C54355233 @default.
• W2966718807 hasConceptScore W2966718807C62478195 @default.
• W2966718807 hasConceptScore W2966718807C86803240 @default.
• W2966718807 hasConceptScore W2966718807C95444343 @default.
• W2966718807 hasLocation W29667188071 @default.
• W2966718807 hasLocation W29667188072 @default.
• W2966718807 hasOpenAccess W2966718807 @default.
• W2966718807 hasPrimaryLocation W29667188071 @default.
• W2966718807 hasRelatedWork W2017159992 @default.
• W2966718807 hasRelatedWork W2028684207 @default.
• W2966718807 hasRelatedWork W2040146393 @default.
• W2966718807 hasRelatedWork W2056239991 @default.

• next