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- W2966725503 abstract "Objective:To study the effects of oxaliplatin on the proliferation and apoptosis of human hepatoma cell line HepG2 and to investigate its mechanism.Methods:The inhibition of HepG2 cell proliferation was estimated by MTT.Morphologic changes under electron microscope were observed.Alteration of cell cycle and apoptosis were analyzed using flow cytometry.The expression of apoptosis-associated genes mutant type p53,Bcl-2,Bax and Fas were detected with immunohistochemical technique.Results:Oxaliplatin could apparently inhibit the growth of HepG2 cells.Cell cycle analysis indicated that oxaliplatin blocked cells in S and G 2/M phase and the apoptosis emerged when treated with oxaliplatin for 72 hours.Under transmission electron microscope,apoptotic body could be found.The expression of genes Bax was up-regulated,the expression of genes mutant type p53,Bcl-2 was down-regulated,while the expression of Fas was not changed.Conclusion:Oxaliplatin can inhibit the proliferation and induce apoptosis of HepG2 cells.The apoptosis is related to the up-regulation apoptotic genes and down-regulation of anti-apoptotic genes." @default.
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- W2966725503 date "2004-01-01" @default.
- W2966725503 modified "2023-09-24" @default.
- W2966725503 title "Study on apoptosis of human hepatoma cell line HepG2 induced by oxaliplatin" @default.
- W2966725503 hasPublicationYear "2004" @default.
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