FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2966745963> ?p ?o ?g. }

• W2966745963 abstract "Purpose Perihematomal edema (PHE) occurs in patients with intracerebral hemorrhage (ICH) and is often used as surrogate of secondary brain injury. PHE resolves over time, but little is known about the functional integrity of the tissues that recover from edema. In a pig ICH model, we aimed to assess metabolic integrity of perihematoma tissues by using noninvasive magnetic resonance spectroscopy (MRS). Material and Methods Fourteen male Yorkshire pigs with an average age of 8 weeks were intracerebrally injected with autologous blood to produce ICH. Proton MRS data were obtained at 1, 7, and 14 days after ICH using a whole-body 3.0T MRI system. Point-resolved spectroscopy (PRESS)-localized 2D chemical shift imaging (CSI) was acquired. The concentration of N-Acetylaspartate (NAA), Choline (Cho), and Creatine (Cr) were measured within the area of PHE, tissues adjacent to the injury with no or negligible edema (ATNE), and contralesional brain tissue. A linear mixed model was used to analyze the evolution of metabolites in perihematomal tissues, with p-value < 0.05 indicating statistical significance. Results The perihematoma volume gradually decreased from 2.38 ± 1.23 ml to 0.41 ± 0.780 ml (p < 0.001) over 2 weeks. Significant (p < 0.001) reductions in NAA, Cr, and Cho concentrations were found in the PHE and ATNE regions compared to the contralesional hemisphere at day 1 and day 7 after ICH. All three metabolites were significantly (p < 0.001) restored in the PHE tissue on day 14, but remained persistently low in the ATNE area, and unaltered in the contralesional voxel. Conclusions This study highlights the potential of MRS to probe salvageable tissues within the perihematoma in the sub-acute phase of intracerebral hemorrhage. Altered metabolites within the PHE and ATNE regions in addition to edema and hematoma volumes were explored as possible markers for tissue recovery. Perihematomal tissue with PHE demonstrated a more reversible injury compared to the tissue adjacent to the injury without edema, suggesting a potentially beneficial role of edema." @default.
• W2966745963 created "2019-08-13" @default.
• W2966745963 creator A5001123414 @default.
• W2966745963 creator A5007665119 @default.
• W2966745963 creator A5007916654 @default.
• W2966745963 creator A5013488261 @default.
• W2966745963 creator A5039968969 @default.
• W2966745963 creator A5051924474 @default.
• W2966745963 creator A5060060979 @default.
• W2966745963 creator A5064530213 @default.
• W2966745963 creator A5073568638 @default.
• W2966745963 creator A5074378595 @default.
• W2966745963 creator A5090372085 @default.
• W2966745963 date "2019-08-21" @default.
• W2966745963 modified "2023-09-27" @default.
• W2966745963 title "Serial Metabolic Evaluation of Perihematomal Tissues in the Intracerebral Hemorrhage Pig Model" @default.
• W2966745963 cites W1965705385 @default.
• W2966745963 cites W1968037251 @default.
• W2966745963 cites W1968514614 @default.
• W2966745963 cites W1969348807 @default.
• W2966745963 cites W1979201601 @default.
• W2966745963 cites W1985573686 @default.
• W2966745963 cites W1990282151 @default.
• W2966745963 cites W1990311126 @default.
• W2966745963 cites W1990603467 @default.
• W2966745963 cites W2004565920 @default.
• W2966745963 cites W2016897470 @default.
• W2966745963 cites W2024020077 @default.
• W2966745963 cites W2030529426 @default.
• W2966745963 cites W2035422580 @default.
• W2966745963 cites W2040084521 @default.
• W2966745963 cites W2043604922 @default.
• W2966745963 cites W2044124238 @default.
• W2966745963 cites W2059914905 @default.
• W2966745963 cites W2064140255 @default.
• W2966745963 cites W2069100635 @default.
• W2966745963 cites W2070526231 @default.
• W2966745963 cites W2076085295 @default.
• W2966745963 cites W2083600673 @default.
• W2966745963 cites W2086005992 @default.
• W2966745963 cites W2091142824 @default.
• W2966745963 cites W2091447505 @default.
• W2966745963 cites W2102960996 @default.
• W2966745963 cites W2117995382 @default.
• W2966745963 cites W2121063409 @default.
• W2966745963 cites W2123301364 @default.
• W2966745963 cites W2128367489 @default.
• W2966745963 cites W2142511211 @default.
• W2966745963 cites W2159452569 @default.
• W2966745963 cites W2160618548 @default.
• W2966745963 cites W2163524716 @default.
• W2966745963 cites W2166286031 @default.
• W2966745963 cites W2171214687 @default.
• W2966745963 cites W2284438769 @default.
• W2966745963 cites W2305386982 @default.
• W2966745963 cites W2410253138 @default.
• W2966745963 cites W2460504475 @default.
• W2966745963 cites W2503531133 @default.
• W2966745963 cites W2550709646 @default.
• W2966745963 cites W2551428457 @default.
• W2966745963 cites W2576998539 @default.
• W2966745963 cites W2603198003 @default.
• W2966745963 cites W2613217394 @default.
• W2966745963 cites W2734025456 @default.
• W2966745963 cites W2756335804 @default.
• W2966745963 cites W2782489076 @default.
• W2966745963 cites W2787999439 @default.
• W2966745963 cites W2803828979 @default.
• W2966745963 cites W2887567733 @default.
• W2966745963 cites W2897582587 @default.
• W2966745963 cites W2898998744 @default.
• W2966745963 cites W2906601044 @default.
• W2966745963 cites W3171831654 @default.
• W2966745963 cites W57576912 @default.
• W2966745963 cites W85196187 @default.
• W2966745963 doi "https://doi.org/10.3389/fnins.2019.00888" @default.
• W2966745963 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6712426" @default.
• W2966745963 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31496934" @default.
• W2966745963 hasPublicationYear "2019" @default.
• W2966745963 type Work @default.
• W2966745963 sameAs 2966745963 @default.
• W2966745963 citedByCount "12" @default.
• W2966745963 countsByYear W29667459632020 @default.
• W2966745963 countsByYear W29667459632021 @default.
• W2966745963 countsByYear W29667459632022 @default.
• W2966745963 crossrefType "journal-article" @default.
• W2966745963 hasAuthorship W2966745963A5001123414 @default.
• W2966745963 hasAuthorship W2966745963A5007665119 @default.
• W2966745963 hasAuthorship W2966745963A5007916654 @default.
• W2966745963 hasAuthorship W2966745963A5013488261 @default.
• W2966745963 hasAuthorship W2966745963A5039968969 @default.
• W2966745963 hasAuthorship W2966745963A5051924474 @default.
• W2966745963 hasAuthorship W2966745963A5060060979 @default.
• W2966745963 hasAuthorship W2966745963A5064530213 @default.
• W2966745963 hasAuthorship W2966745963A5073568638 @default.
• W2966745963 hasAuthorship W2966745963A5074378595 @default.
• W2966745963 hasAuthorship W2966745963A5090372085 @default.
• W2966745963 hasBestOaLocation W29667459631 @default.
• W2966745963 hasConcept C126322002 @default.
• W2966745963 hasConcept C126838900 @default.

• next