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• W2966881089 abstract "Abstract Objective To retrospectively review the efficacy and safety of novel direct oral anticoagulants ( DOAC s) and compare the results with those of vitamin K antagonists ( VKA ) when used in clinical practice to treat venous thromboembolism ( VTE ) because there is insufficient evidence regarding its use in patients with gynecological cancers. Methods A study was conducted of patients diagnosed with gynecological cancers at Osaka University Hospital between January 2010 and December 2017. The medical records of those who suffered from deep venous thrombosis ( DVT ) and/or pulmonary embolism ( PE ) were retrospectively reviewed. Results Among the 1698 cases of gynecological cancers, 107 (6.3%) cases were diagnosed as having VTE . A total of 34 (31.8%) patients presented DVT plus PE and 73 (68.2%) patients had DVT alone. Fifty‐four cases were treated with DOAC s and 53 with VKA . Although 3 of the 53 patients (5.7%) in the VKA group developed recurrent VTE , only 1 (1.9%) patient in the DOAC group showed clinically relevant bleeding from a tumor penetrating the rectum. DOAC s were non‐inferior to VKA with respect to the composite outcome, including recurrent venous thrombosis and relevant bleeding (hazard ratio 0.31, 95% confidence interval 0.03–3.12, P =0.363). Conclusion DOAC s can be effectively and safely used in VTE patients with gynecological cancers." @default.
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• W2966881089 date "2019-08-29" @default.
• W2966881089 modified "2023-10-16" @default.
• W2966881089 title "Direct oral anticoagulants are effective and safe for the treatment of venous thromboembolism associated with gynecological cancers" @default.
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• W2966881089 doi "https://doi.org/10.1002/ijgo.12944" @default.
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