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- W2966914986 abstract "Integrins mediate the anchorage between cells and their environment, the extracellular matrix (ECM), and form transmembrane links between the ECM and the cytoskeleton, a conserved feature throughout development and morphogenesis of epithelial organs. Here, we demonstrate that integrins and components of the ECM are required during the planar cell polarity (PCP) signalling-regulated cell movement of ommatidial rotation in the Drosophila eye. The loss-of-function mutations of integrins or ECM components cause defects in rotation, with mutant clusters rotating asynchronously compared to wild-type clusters. Initially, mutant clusters tend to rotate faster, and at later stages they fail to be synchronous with their neighbours, leading to aberrant rotation angles and resulting in a disorganized ommatidial arrangement in adult eyes. We further demonstrate that integrin localization changes dynamically during the rotation process. Our data suggest that core Frizzled/PCP factors, acting through RhoA and Rho kinase, regulate the function/activity of integrins and that integrins thus contribute to the complex interaction network of PCP signalling, cell adhesion and cytoskeletal elements required for a precise and synchronous 90° rotation movement." @default.
- W2966914986 created "2019-08-22" @default.
- W2966914986 creator A5008110078 @default.
- W2966914986 creator A5022776643 @default.
- W2966914986 creator A5055410574 @default.
- W2966914986 creator A5057019157 @default.
- W2966914986 creator A5078607394 @default.
- W2966914986 creator A5079205928 @default.
- W2966914986 date "2019-08-01" @default.
- W2966914986 modified "2023-10-16" @default.
- W2966914986 title "Integrins are required for synchronous ommatidial rotation in the <i>Drosophila</i> eye linking planar cell polarity signalling to the extracellular matrix" @default.
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