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• W2966925675 endingPage "117" @default.
• W2966925675 startingPage "117" @default.
• W2966925675 abstract "Ribosomally-synthesized and post-translationally modified peptides (RiPPs) are a large class of natural products produced across all domains of life. The lasso peptides, a subclass of RiPPs with a lasso-like structure, are structurally and functionally unique compared to other known peptide antibiotics in that the linear peptide is literally “tied in a knot” during its post-translational maturation. This underexplored class of peptides brings chemical diversity and unique modes of action to the antibiotic space. To date, eight different lasso peptides have been shown to target three known molecular machines: RNA polymerase, the lipid II precursor in peptidoglycan biosynthesis, and the ClpC1 subunit of the Clp protease involved in protein homeostasis. Here, we discuss the current knowledge on lasso peptide biosynthesis as well as their antibiotic activity, molecular targets, and mechanisms of action." @default.
• W2966925675 created "2019-08-22" @default.
• W2966925675 creator A5007844047 @default.
• W2966925675 creator A5068704503 @default.
• W2966925675 creator A5079237039 @default.
• W2966925675 date "2019-08-11" @default.
• W2966925675 modified "2023-10-16" @default.
• W2966925675 title "Put a Bow on It: Knotted Antibiotics Take Center Stage" @default.
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• W2966925675 doi "https://doi.org/10.3390/antibiotics8030117" @default.
• W2966925675 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6784204" @default.
• W2966925675 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31405236" @default.
• W2966925675 hasPublicationYear "2019" @default.
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