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- W2966936789 abstract "Aims and method To investigate the percentage of patients who commenced smoking after transferring out of a non-smoking forensic psychiatric unit, the corresponding clozapine dose adjustments, the effects on plasma clozapine/norclozapine concentrations and observed changes in mental state. We reviewed the notes and plasma clozapine/norclozapine concentrations of 46 patients transferred to medium secure units between July 2008 and December 2013. Results Thirty-five patients commenced smoking. Their median clozapine dose was increased by 50 mg/d. In the non-smokers, the median clozapine dose remained unchanged. Plasma clozapine/norclozapine concentrations were significantly reduced in smokers despite dosage adjustment. Eighteen patients experienced deterioration in mental state after transfer; almost all these patients were smokers. Clinical implications Approximately three-quarters of patients who were non-smokers by virtue of being in a secure non-smoking environment commenced smoking after transfer. Monitoring of clozapine serum levels and assessment of mental state in the immediate period after a change in smoking status is indicated." @default.
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- W2966936789 date "2019-08-08" @default.
- W2966936789 modified "2023-09-24" @default.
- W2966936789 title "Changes in smoking status, mental state and plasma clozapine concentration: retrospective cohort evaluation" @default.
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- W2966936789 doi "https://doi.org/10.1192/bjb.2019.50" @default.
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