Matches in SemOpenAlex for { <https://semopenalex.org/work/W2966966002> ?p ?o ?g. }
- W2966966002 abstract "Abstract Infection with a single influenza A virus (IAV) is only rarely sufficient to initiate productive infection. Here, we exploit both single-cell approaches and whole-animal systems to show that IAV reliance on multiple infection can form an important species barrier to infection. Namely, we find that H9N2 subtype viruses representative of those circulating widely at the poultry-human interface exhibit acute dependence on collective interactions in mammalian systems. This need for multiple infection is greatly reduced in the natural host. Quantification of incomplete viral genomes showed that their complementation accounts for the more moderate reliance on coinfection seen in avian cells, but not the added reliance seen in mammalian cells. This finding suggests an additional form of virus-virus interaction is needed to support infection in mammalian cells. Genetic mapping implicated the PA gene segment as a major driver of this phenotype and quantification of viral RNA synthesis indicated that both replication and transcription were affected. These findings indicate that multiple distinct mechanisms underlie IAV reliance on multiple infection and underscore the importance of virus-virus interactions in IAV infection, evolution and emergence." @default.
- W2966966002 created "2019-08-22" @default.
- W2966966002 creator A5002578800 @default.
- W2966966002 creator A5022673901 @default.
- W2966966002 creator A5030812070 @default.
- W2966966002 creator A5042170161 @default.
- W2966966002 creator A5061715474 @default.
- W2966966002 creator A5063405976 @default.
- W2966966002 creator A5077341701 @default.
- W2966966002 creator A5081038591 @default.
- W2966966002 creator A5082271001 @default.
- W2966966002 creator A5085780264 @default.
- W2966966002 creator A5086135097 @default.
- W2966966002 creator A5091013703 @default.
- W2966966002 date "2019-08-15" @default.
- W2966966002 modified "2023-10-14" @default.
- W2966966002 title "Collective interactions augment influenza A virus replication in a host-dependent manner" @default.
- W2966966002 cites W1478284728 @default.
- W2966966002 cites W1574277876 @default.
- W2966966002 cites W1982660013 @default.
- W2966966002 cites W1989481626 @default.
- W2966966002 cites W1999336249 @default.
- W2966966002 cites W2001788095 @default.
- W2966966002 cites W2007096813 @default.
- W2966966002 cites W2014169878 @default.
- W2966966002 cites W2022825068 @default.
- W2966966002 cites W2026343756 @default.
- W2966966002 cites W2031396613 @default.
- W2966966002 cites W2044600321 @default.
- W2966966002 cites W2052811733 @default.
- W2966966002 cites W2065705389 @default.
- W2966966002 cites W2067142065 @default.
- W2966966002 cites W2067684202 @default.
- W2966966002 cites W2068880378 @default.
- W2966966002 cites W2072676693 @default.
- W2966966002 cites W2083889661 @default.
- W2966966002 cites W2087189381 @default.
- W2966966002 cites W2089692155 @default.
- W2966966002 cites W2091527885 @default.
- W2966966002 cites W2092097938 @default.
- W2966966002 cites W2099212793 @default.
- W2966966002 cites W2099235928 @default.
- W2966966002 cites W2099626939 @default.
- W2966966002 cites W2100264429 @default.
- W2966966002 cites W2103428668 @default.
- W2966966002 cites W2106338305 @default.
- W2966966002 cites W2120474334 @default.
- W2966966002 cites W2121260217 @default.
- W2966966002 cites W2122242794 @default.
- W2966966002 cites W2131346503 @default.
- W2966966002 cites W2133554652 @default.
- W2966966002 cites W2139556812 @default.
- W2966966002 cites W2146335827 @default.
- W2966966002 cites W2146607614 @default.
- W2966966002 cites W2148734478 @default.
- W2966966002 cites W2150614361 @default.
- W2966966002 cites W2150888997 @default.
- W2966966002 cites W2154403354 @default.
- W2966966002 cites W2158052175 @default.
- W2966966002 cites W2158073495 @default.
- W2966966002 cites W2164121350 @default.
- W2966966002 cites W2169886642 @default.
- W2966966002 cites W2170535835 @default.
- W2966966002 cites W2170585188 @default.
- W2966966002 cites W2177085441 @default.
- W2966966002 cites W2198001007 @default.
- W2966966002 cites W2256756668 @default.
- W2966966002 cites W2262759738 @default.
- W2966966002 cites W2301015295 @default.
- W2966966002 cites W2470517214 @default.
- W2966966002 cites W2511108086 @default.
- W2966966002 cites W2547923226 @default.
- W2966966002 cites W2594725970 @default.
- W2966966002 cites W2620052976 @default.
- W2966966002 cites W2705666013 @default.
- W2966966002 cites W2752486236 @default.
- W2966966002 cites W2754820381 @default.
- W2966966002 cites W2759082725 @default.
- W2966966002 cites W2768072103 @default.
- W2966966002 cites W2772085864 @default.
- W2966966002 cites W2772517777 @default.
- W2966966002 cites W2776528073 @default.
- W2966966002 cites W2810988926 @default.
- W2966966002 cites W2887691821 @default.
- W2966966002 cites W2890372864 @default.
- W2966966002 cites W2891842318 @default.
- W2966966002 cites W2897379694 @default.
- W2966966002 cites W2897943784 @default.
- W2966966002 cites W2903201721 @default.
- W2966966002 cites W2914599048 @default.
- W2966966002 cites W2949656621 @default.
- W2966966002 cites W2950506491 @default.
- W2966966002 cites W2951190177 @default.
- W2966966002 cites W2951506174 @default.
- W2966966002 cites W2965596364 @default.
- W2966966002 cites W2966550237 @default.
- W2966966002 cites W2971497300 @default.
- W2966966002 cites W4245436919 @default.
- W2966966002 cites W4247635995 @default.
- W2966966002 cites W4255086890 @default.