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• W2967006114 abstract "Abstract Uncontrolled systemic inflammatory immune triggering has hampered the clinical translation of several classes of small‐molecule immunomodulators, such as imidazoquinoline TLR7/8 agonists for vaccine design and cancer immunotherapy. By taking advantage of the inherent serum‐protein‐binding property of lipid motifs and their tendency to accumulate in lymphoid tissue, we designed amphiphilic lipid–polymer conjugates that suppress systemic inflammation but provoke potent lymph‐node immune activation. This work provides a rational basis for the design of lipid–polymer amphiphiles for optimized lymphoid targeting." @default.
• W2967006114 created "2019-08-22" @default.
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• W2967006114 date "2019-09-12" @default.
• W2967006114 modified "2023-10-01" @default.
• W2967006114 title "Potent Lymphatic Translocation and Spatial Control Over Innate Immune Activation by Polymer–Lipid Amphiphile Conjugates of Small‐Molecule TLR7/8 Agonists" @default.
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• W2967006114 doi "https://doi.org/10.1002/anie.201905687" @default.
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