FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2967040283> ?p ?o ?g. }

• W2967040283 endingPage "449" @default.
• W2967040283 startingPage "448" @default.
• W2967040283 abstract "1903 Introduction: Metastatic malignant melanoma is an extremely aggressive cancer with no current viable therapy. A unique non-toxic nutrient mixture (NM) consisting of lysine, proline, ascorbic acid and green tea extract has shown potent anti-tumor effects in a number of cancer cell lines in vitro and in vivo. Objective: The present study investigated whether NM could also inhibit lung metastasis by B16F0 melanoma cell in C57BL/6 female mice. Method and Materials: C57BL/6 female mice were divided into 6 groups of 6 mice per group; Groups 1-4 were injected via tail vein with B16F0 melanoma cells (5x104/mouse) and Group 5 (control group) received the vehicle saline. Group 1 was fed the control diet, Group 2 was fed the same diet supplemented with 0.5% NM, Group 3 and 4 were given NM by IP and IV (4 mg/mouse, three times a week) respectively, and fed the control diet. Group 6 mice were fed the control diet but injected with B16F0 melanoma cells pretreated with NM (500 μg/ml for 24 hrs). In another study, mice were injected either with 106 or 105 B16F melanoma cells per mouse and divided into four groups (A-D). Groups A ,C were fed the control diet, while Groups B, D fed the same diet supplemented with 0.5% NM. Two weeks later mice in all the groups were euthanized, lungs were excised, weighed, fixed, pulmonary metastatic colonies were counted, and lung tissue processed for histology. Results: Pulmonary colonization was reduced to 63% in Group 2 (NM diet) compared to Group 1 (control). Pulmonary colonization was further inhibited by 86% in mice receiving MN by ip and iv injections (Groups 3, 4). Complete inhibition of pulmonary colonization was seen in mice that received melanoma cells pretreated with NM (Group 6). Findings were corroborated with histological analysis. Furthermore, inhibitory effect of NM was also confirmed by comparing the weight of lungs. Of mice that received 106 cells, the NM fed group (B) had an average lung weight of 0.55 gm, compared to 0.92 gm in the control group (A). Histopathology revealed metastasis in all lobes with back-to-back colonies. Similar inhibition was seen in the mice that received 105 cells. For example, an average lung weight of mice fed NM (Group D) was 0.11, compared to 0.15 gm in mice fed the control diet (Group E). Metastasis involved 40-45% of the lung. The average number of colonies in control Group C was 600, while in NM-fed Group D it was 400 (33% reduction). Results from the control and the test groups for weight of lungs and number of cells inoculated were pooled and the correlation coefficient was calculated. An excellent correlation was obtained (r=0.93, P" @default.
• W2967040283 created "2019-08-22" @default.
• W2967040283 creator A5003848269 @default.
• W2967040283 creator A5039078005 @default.
• W2967040283 creator A5075296153 @default.
• W2967040283 creator A5078266408 @default.
• W2967040283 creator A5086331722 @default.
• W2967040283 date "2006-04-15" @default.
• W2967040283 modified "2023-09-23" @default.
• W2967040283 title "A nutrient mixture consisting of lysine, proline, ascorbic acid and green tea extract inhibits lung metastasis by B16 melanoma cells in mice" @default.
• W2967040283 hasPublicationYear "2006" @default.
• W2967040283 type Work @default.
• W2967040283 sameAs 2967040283 @default.
• W2967040283 citedByCount "0" @default.
• W2967040283 crossrefType "journal-article" @default.
• W2967040283 hasAuthorship W2967040283A5003848269 @default.
• W2967040283 hasAuthorship W2967040283A5039078005 @default.
• W2967040283 hasAuthorship W2967040283A5075296153 @default.
• W2967040283 hasAuthorship W2967040283A5078266408 @default.
• W2967040283 hasAuthorship W2967040283A5086331722 @default.
• W2967040283 hasConcept C121608353 @default.
• W2967040283 hasConcept C126322002 @default.
• W2967040283 hasConcept C142724271 @default.
• W2967040283 hasConcept C150903083 @default.
• W2967040283 hasConcept C202751555 @default.
• W2967040283 hasConcept C203014093 @default.
• W2967040283 hasConcept C207001950 @default.
• W2967040283 hasConcept C2777658100 @default.
• W2967040283 hasConcept C2777714996 @default.
• W2967040283 hasConcept C2779013556 @default.
• W2967040283 hasConcept C2986274086 @default.
• W2967040283 hasConcept C31903555 @default.
• W2967040283 hasConcept C502942594 @default.
• W2967040283 hasConcept C55493867 @default.
• W2967040283 hasConcept C71924100 @default.
• W2967040283 hasConcept C86803240 @default.
• W2967040283 hasConceptScore W2967040283C121608353 @default.
• W2967040283 hasConceptScore W2967040283C126322002 @default.
• W2967040283 hasConceptScore W2967040283C142724271 @default.
• W2967040283 hasConceptScore W2967040283C150903083 @default.
• W2967040283 hasConceptScore W2967040283C202751555 @default.
• W2967040283 hasConceptScore W2967040283C203014093 @default.
• W2967040283 hasConceptScore W2967040283C207001950 @default.
• W2967040283 hasConceptScore W2967040283C2777658100 @default.
• W2967040283 hasConceptScore W2967040283C2777714996 @default.
• W2967040283 hasConceptScore W2967040283C2779013556 @default.
• W2967040283 hasConceptScore W2967040283C2986274086 @default.
• W2967040283 hasConceptScore W2967040283C31903555 @default.
• W2967040283 hasConceptScore W2967040283C502942594 @default.
• W2967040283 hasConceptScore W2967040283C55493867 @default.
• W2967040283 hasConceptScore W2967040283C71924100 @default.
• W2967040283 hasConceptScore W2967040283C86803240 @default.
• W2967040283 hasLocation W29670402831 @default.
• W2967040283 hasOpenAccess W2967040283 @default.
• W2967040283 hasPrimaryLocation W29670402831 @default.
• W2967040283 hasRelatedWork W2033972775 @default.
• W2967040283 hasRelatedWork W2121523180 @default.
• W2967040283 hasRelatedWork W2356481950 @default.
• W2967040283 hasRelatedWork W2357355043 @default.
• W2967040283 hasRelatedWork W2359107428 @default.
• W2967040283 hasRelatedWork W2359434455 @default.
• W2967040283 hasRelatedWork W2361006437 @default.
• W2967040283 hasRelatedWork W2362923964 @default.
• W2967040283 hasRelatedWork W2369189059 @default.
• W2967040283 hasRelatedWork W2376976586 @default.
• W2967040283 hasRelatedWork W2377564385 @default.
• W2967040283 hasRelatedWork W2392475984 @default.
• W2967040283 hasRelatedWork W2393932103 @default.
• W2967040283 hasRelatedWork W2401819357 @default.
• W2967040283 hasRelatedWork W2404733004 @default.
• W2967040283 hasRelatedWork W2415202645 @default.
• W2967040283 hasRelatedWork W2418436204 @default.
• W2967040283 hasRelatedWork W2491501156 @default.
• W2967040283 hasRelatedWork W3028807018 @default.
• W2967040283 hasRelatedWork W3032829073 @default.
• W2967040283 hasVolume "66" @default.
• W2967040283 isParatext "false" @default.
• W2967040283 isRetracted "false" @default.
• W2967040283 magId "2967040283" @default.
• W2967040283 workType "article" @default.