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- W2967052232 endingPage "3918" @default.
- W2967052232 startingPage "3918" @default.
- W2967052232 abstract "Obesity is a rising public health problem that contributes to the development of several metabolic diseases and cancer. Adipocyte precursors outside of adipose depots that expand due to overweight and obesity may have a negative impact on human health. Determining how progenitor cells acquire a preadipocyte commitment and become mature adipocytes remains a significant challenge. Over the past several years, we have learned that the establishment of cellular identity is widely influenced by changes in histone marks, which in turn modulate chromatin structure. In this regard, histone lysine demethylases (KDMs) are now emerging as key players that shape chromatin through their ability to demethylate almost all major histone methylation sites. Recent research has shown that KDMs orchestrate the chromatin landscape, which mediates the activation of adipocyte-specific genes. In addition, KDMs have functions in addition to their enzymatic activity, which are beginning to be revealed, and their dysregulation seems to be related to the development of metabolic disorders. In this review, we highlight the biological functions of KDMs that contribute to the establishment of a permissive or repressive chromatin environment during the mesenchymal stem cell transition into adipocytes. Understanding how KDMs regulate adipogenesis might prompt the development of new strategies for fighting obesity-related diseases." @default.
- W2967052232 created "2019-08-22" @default.
- W2967052232 creator A5004865375 @default.
- W2967052232 creator A5011852169 @default.
- W2967052232 creator A5027551166 @default.
- W2967052232 creator A5029353761 @default.
- W2967052232 creator A5061418324 @default.
- W2967052232 creator A5067520833 @default.
- W2967052232 creator A5080879961 @default.
- W2967052232 date "2019-08-12" @default.
- W2967052232 modified "2023-10-03" @default.
- W2967052232 title "Epigenetic Regulation of Adipogenic Differentiation by Histone Lysine Demethylation" @default.
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