Matches in SemOpenAlex for { <https://semopenalex.org/work/W2967057777> ?p ?o ?g. }
Showing items 1 to 94 of
94
with 100 items per page.
- W2967057777 abstract "The aim of the present study was to evaluate the neuroprotective effect of Citrus aurantium extract (CAE) and nobiletin against amyloid β 1‑42 (Aβ 1‑42)‑induced spatial learning and memory impairment in mice. After injecting Aβ 1‑42 (5 µl/2.5 min, intracerebroventricular injection), amnesic mice were orally administered CAE and nobiletin for 28 days. Memory, spatial and cognitive ability were measured using passive avoidance and a Morris water maze task. Acetylcholinesterase (AchE) activity was investigated in the hippocampus and cortex using commercial kits and the analysis of Bax, Bcl‑2, and cleaved caspase‑3 protein expression by western blot assays was used to confirm the anti‑apoptotic mechanism of CAE and nobiletin. The present study confirmed impairments in learning and memory in the Aβ‑induced neurodegenerative mice with increased AchE activity in the brain. However, the daily administration of CAE and nobiletin reduced the spatial learning deficits and increased the AchE activity in the cortex and hippocampus. Furthermore, CAE and nobiletin significantly downregulated the Bax and cleaved caspase‑3 protein expression and upregulated the Bcl‑2 and Bcl‑2/Bax expression in the cortex and hippocampus of Aβ‑treated mice. These results suggest that CAE and nobiletin exert a neuroprotective effect by regulating anti‑apoptotic mechanisms, including reduced AchE activity in the cortex and hippocampus of the cognitive deficit mouse model." @default.
- W2967057777 created "2019-08-22" @default.
- W2967057777 creator A5001034843 @default.
- W2967057777 creator A5024236987 @default.
- W2967057777 creator A5073013969 @default.
- W2967057777 creator A5075049645 @default.
- W2967057777 creator A5075410785 @default.
- W2967057777 creator A5087847305 @default.
- W2967057777 date "2019-08-09" @default.
- W2967057777 modified "2023-10-15" @default.
- W2967057777 title "Ameliorating effect of Citrus�aurantium extracts and nobiletin on β‑amyloid (1‑42)‑induced memory impairment in mice" @default.
- W2967057777 doi "https://doi.org/10.3892/mmr.2019.10582" @default.
- W2967057777 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31432129" @default.
- W2967057777 hasPublicationYear "2019" @default.
- W2967057777 type Work @default.
- W2967057777 sameAs 2967057777 @default.
- W2967057777 citedByCount "7" @default.
- W2967057777 countsByYear W29670577772020 @default.
- W2967057777 countsByYear W29670577772021 @default.
- W2967057777 countsByYear W29670577772022 @default.
- W2967057777 crossrefType "journal-article" @default.
- W2967057777 hasAuthorship W2967057777A5001034843 @default.
- W2967057777 hasAuthorship W2967057777A5024236987 @default.
- W2967057777 hasAuthorship W2967057777A5073013969 @default.
- W2967057777 hasAuthorship W2967057777A5075049645 @default.
- W2967057777 hasAuthorship W2967057777A5075410785 @default.
- W2967057777 hasAuthorship W2967057777A5087847305 @default.
- W2967057777 hasBestOaLocation W29670577771 @default.
- W2967057777 hasConcept C104317684 @default.
- W2967057777 hasConcept C126322002 @default.
- W2967057777 hasConcept C134018914 @default.
- W2967057777 hasConcept C15744967 @default.
- W2967057777 hasConcept C169760540 @default.
- W2967057777 hasConcept C181199279 @default.
- W2967057777 hasConcept C185592680 @default.
- W2967057777 hasConcept C190283241 @default.
- W2967057777 hasConcept C25498285 @default.
- W2967057777 hasConcept C2776415932 @default.
- W2967057777 hasConcept C2777348757 @default.
- W2967057777 hasConcept C2778004101 @default.
- W2967057777 hasConcept C2778401301 @default.
- W2967057777 hasConcept C2778816929 @default.
- W2967057777 hasConcept C2779054382 @default.
- W2967057777 hasConcept C2779059548 @default.
- W2967057777 hasConcept C2779134260 @default.
- W2967057777 hasConcept C2779483572 @default.
- W2967057777 hasConcept C2780904820 @default.
- W2967057777 hasConcept C2781161787 @default.
- W2967057777 hasConcept C44752575 @default.
- W2967057777 hasConcept C55493867 @default.
- W2967057777 hasConcept C71924100 @default.
- W2967057777 hasConcept C98274493 @default.
- W2967057777 hasConceptScore W2967057777C104317684 @default.
- W2967057777 hasConceptScore W2967057777C126322002 @default.
- W2967057777 hasConceptScore W2967057777C134018914 @default.
- W2967057777 hasConceptScore W2967057777C15744967 @default.
- W2967057777 hasConceptScore W2967057777C169760540 @default.
- W2967057777 hasConceptScore W2967057777C181199279 @default.
- W2967057777 hasConceptScore W2967057777C185592680 @default.
- W2967057777 hasConceptScore W2967057777C190283241 @default.
- W2967057777 hasConceptScore W2967057777C25498285 @default.
- W2967057777 hasConceptScore W2967057777C2776415932 @default.
- W2967057777 hasConceptScore W2967057777C2777348757 @default.
- W2967057777 hasConceptScore W2967057777C2778004101 @default.
- W2967057777 hasConceptScore W2967057777C2778401301 @default.
- W2967057777 hasConceptScore W2967057777C2778816929 @default.
- W2967057777 hasConceptScore W2967057777C2779054382 @default.
- W2967057777 hasConceptScore W2967057777C2779059548 @default.
- W2967057777 hasConceptScore W2967057777C2779134260 @default.
- W2967057777 hasConceptScore W2967057777C2779483572 @default.
- W2967057777 hasConceptScore W2967057777C2780904820 @default.
- W2967057777 hasConceptScore W2967057777C2781161787 @default.
- W2967057777 hasConceptScore W2967057777C44752575 @default.
- W2967057777 hasConceptScore W2967057777C55493867 @default.
- W2967057777 hasConceptScore W2967057777C71924100 @default.
- W2967057777 hasConceptScore W2967057777C98274493 @default.
- W2967057777 hasLocation W29670577771 @default.
- W2967057777 hasLocation W29670577772 @default.
- W2967057777 hasOpenAccess W2967057777 @default.
- W2967057777 hasPrimaryLocation W29670577771 @default.
- W2967057777 hasRelatedWork W2107162021 @default.
- W2967057777 hasRelatedWork W2158042711 @default.
- W2967057777 hasRelatedWork W2349076958 @default.
- W2967057777 hasRelatedWork W2378845176 @default.
- W2967057777 hasRelatedWork W2388468533 @default.
- W2967057777 hasRelatedWork W2912142776 @default.
- W2967057777 hasRelatedWork W2967057777 @default.
- W2967057777 hasRelatedWork W2996100361 @default.
- W2967057777 hasRelatedWork W3174785593 @default.
- W2967057777 hasRelatedWork W3196399992 @default.
- W2967057777 isParatext "false" @default.
- W2967057777 isRetracted "false" @default.
- W2967057777 magId "2967057777" @default.
- W2967057777 workType "article" @default.