Matches in SemOpenAlex for { <https://semopenalex.org/work/W2967097514> ?p ?o ?g. }
Showing items 1 to 97 of
97
with 100 items per page.
- W2967097514 endingPage "73" @default.
- W2967097514 startingPage "67" @default.
- W2967097514 abstract "In this study, doxorubicin (DOX)-induced cardiotoxicity was overcome using cancer-recognizable DOX-loaded acetylated hyaluronic aicd-poly(L-lactic acid) (AcHA-PLLA) nanoparticles (DHPs). AcHA-PLLA was synthesized via ring opening polymerization of L-lactide with AcHA as a macroinitiator and characterized by 1H NMR and critical micelle concentration. DHPs were formed by self-assembly via dialysis, were estimated to be 160.7 ± 2.7 nm in average diameter, exhibited a slow rate release profile, and prevented DOX from being degraded in the circulation. In addition, DHPs demonstrated efficient cellular uptake into a colorectal cancer cell line (HCT-116) by CD44 receptor-mediated endocytosis, which was confirmed by in vitro cellular uptake, the competitive inhibition assay with free HA and flow cytometry. Furthermore, DHPs exhibited therapeutic efficacy against HCT-116 cells through receptor-mediated endocytosis: DHPs with free hyaluronic acid (HA) demonstrated 2-fold higher cell viability than DHPs without free HA. DHPs also inhibited doxorubicinol production, which induces cardiotoxicity, from DOX in vivo. The area-under-the-curve (AUC) of DOX administered as free DOX was 109.0 ± 25.0 µg min mL−1 and that from DHPs was 97.2 ± 10.2 µg min mL−1. Although these are comparable, the AUC of doxorubicinol was 1.36 ± 0.18 µg min mL−1 and 0.45 ± 0.12 µg min mL−1, with the treatment of free DOX-HCl and DHPs, respectively, demonstrating the reduction of the metabolic conversion of DOX to doxorubicinol in plasma. These results indicate the role of DHPs in preventing DOX transformation into doxorubicinol, which may contribute to the reduced toxicity. DHPs are promising cancer therapeutic nanoparticles, because they are highly biocompatible and tumor-recognizable, and prevent the DOX transformation.." @default.
- W2967097514 created "2019-08-22" @default.
- W2967097514 creator A5022302594 @default.
- W2967097514 creator A5032157494 @default.
- W2967097514 creator A5055230701 @default.
- W2967097514 creator A5067328906 @default.
- W2967097514 date "2019-08-16" @default.
- W2967097514 modified "2023-10-16" @default.
- W2967097514 title "Acetylated Hyaluronic Acid-Poly(L-lactic acid) Conjugate Nanoparticles for Inhibition of Doxorubicinol Production from Doxorubicin" @default.
- W2967097514 cites W1987402110 @default.
- W2967097514 cites W1989230986 @default.
- W2967097514 cites W2003474213 @default.
- W2967097514 cites W2012192482 @default.
- W2967097514 cites W2012727362 @default.
- W2967097514 cites W2020707689 @default.
- W2967097514 cites W2033275957 @default.
- W2967097514 cites W2036861357 @default.
- W2967097514 cites W2071259865 @default.
- W2967097514 cites W2076432566 @default.
- W2967097514 cites W2090169401 @default.
- W2967097514 cites W2113921694 @default.
- W2967097514 cites W2176395572 @default.
- W2967097514 cites W2179022277 @default.
- W2967097514 cites W2223635015 @default.
- W2967097514 cites W2328379439 @default.
- W2967097514 cites W2332911520 @default.
- W2967097514 cites W2909437471 @default.
- W2967097514 doi "https://doi.org/10.1007/s13233-020-8003-6" @default.
- W2967097514 hasPublicationYear "2019" @default.
- W2967097514 type Work @default.
- W2967097514 sameAs 2967097514 @default.
- W2967097514 citedByCount "4" @default.
- W2967097514 countsByYear W29670975142020 @default.
- W2967097514 countsByYear W29670975142022 @default.
- W2967097514 crossrefType "journal-article" @default.
- W2967097514 hasAuthorship W2967097514A5022302594 @default.
- W2967097514 hasAuthorship W2967097514A5032157494 @default.
- W2967097514 hasAuthorship W2967097514A5055230701 @default.
- W2967097514 hasAuthorship W2967097514A5067328906 @default.
- W2967097514 hasBestOaLocation W29670975141 @default.
- W2967097514 hasConcept C105702510 @default.
- W2967097514 hasConcept C134306372 @default.
- W2967097514 hasConcept C141071460 @default.
- W2967097514 hasConcept C1491633281 @default.
- W2967097514 hasConcept C185592680 @default.
- W2967097514 hasConcept C197336794 @default.
- W2967097514 hasConcept C203014093 @default.
- W2967097514 hasConcept C2776694085 @default.
- W2967097514 hasConcept C2777529286 @default.
- W2967097514 hasConcept C2778048844 @default.
- W2967097514 hasConcept C2778371730 @default.
- W2967097514 hasConcept C2780866276 @default.
- W2967097514 hasConcept C2781303535 @default.
- W2967097514 hasConcept C28005876 @default.
- W2967097514 hasConcept C33923547 @default.
- W2967097514 hasConcept C55493867 @default.
- W2967097514 hasConcept C71924100 @default.
- W2967097514 hasConcept C98274493 @default.
- W2967097514 hasConceptScore W2967097514C105702510 @default.
- W2967097514 hasConceptScore W2967097514C134306372 @default.
- W2967097514 hasConceptScore W2967097514C141071460 @default.
- W2967097514 hasConceptScore W2967097514C1491633281 @default.
- W2967097514 hasConceptScore W2967097514C185592680 @default.
- W2967097514 hasConceptScore W2967097514C197336794 @default.
- W2967097514 hasConceptScore W2967097514C203014093 @default.
- W2967097514 hasConceptScore W2967097514C2776694085 @default.
- W2967097514 hasConceptScore W2967097514C2777529286 @default.
- W2967097514 hasConceptScore W2967097514C2778048844 @default.
- W2967097514 hasConceptScore W2967097514C2778371730 @default.
- W2967097514 hasConceptScore W2967097514C2780866276 @default.
- W2967097514 hasConceptScore W2967097514C2781303535 @default.
- W2967097514 hasConceptScore W2967097514C28005876 @default.
- W2967097514 hasConceptScore W2967097514C33923547 @default.
- W2967097514 hasConceptScore W2967097514C55493867 @default.
- W2967097514 hasConceptScore W2967097514C71924100 @default.
- W2967097514 hasConceptScore W2967097514C98274493 @default.
- W2967097514 hasIssue "1" @default.
- W2967097514 hasLocation W29670975141 @default.
- W2967097514 hasOpenAccess W2967097514 @default.
- W2967097514 hasPrimaryLocation W29670975141 @default.
- W2967097514 hasRelatedWork W1586940161 @default.
- W2967097514 hasRelatedWork W1982663944 @default.
- W2967097514 hasRelatedWork W2062677292 @default.
- W2967097514 hasRelatedWork W2256197395 @default.
- W2967097514 hasRelatedWork W2364310920 @default.
- W2967097514 hasRelatedWork W2565987670 @default.
- W2967097514 hasRelatedWork W2735779668 @default.
- W2967097514 hasRelatedWork W2997886168 @default.
- W2967097514 hasRelatedWork W4205905439 @default.
- W2967097514 hasRelatedWork W4210797630 @default.
- W2967097514 hasVolume "28" @default.
- W2967097514 isParatext "false" @default.
- W2967097514 isRetracted "false" @default.
- W2967097514 magId "2967097514" @default.
- W2967097514 workType "article" @default.