Matches in SemOpenAlex for { <https://semopenalex.org/work/W2967149063> ?p ?o ?g. }
- W2967149063 endingPage "40" @default.
- W2967149063 startingPage "30" @default.
- W2967149063 abstract "Abstract Homozygous loss of function of the melanocortin 1 receptor (MC1R) is associated with a pheomelanotic pigment phenotype and increased melanoma risk. MC1R heterozygosity is less well studied, although individuals inheriting one loss‐of‐function MC1R allele are also melanoma‐prone. Using the K14‐Scf C57BL/6J animal model whose skin is characterized by lifelong retention of interfollicular epidermal melanocytes like that of the human, we studied pigmentary, UV responses, and DNA repair capacity in the skin of variant Mc1r background. Topical application of forskolin, a skin‐permeable pharmacologic activator of cAMP induction to mimic native Mc1r signaling, increased epidermal eumelanin levels, increased the capacity of Mc1r ‐heterozygous skin to resist UV‐mediated inflammation, and enhanced the skin's ability to clear UV photolesions from DNA. Interestingly, topical cAMP induction also promoted melanin accumulation, UV resistance, and accelerated clearance in Mc1r fully intact skin. Together, our findings suggest that heterozygous Mc1r loss is associated with an intermediately melanized and DNA repair‐proficient epidermal phenotype and that topical cAMP induction enhances UV resistance in Mc1r ‐heterozygous or Mc1r ‐wild‐type individuals by increasing eumelanin deposition and by improving nucleotide excision repair." @default.
- W2967149063 created "2019-08-22" @default.
- W2967149063 creator A5010983774 @default.
- W2967149063 creator A5018391981 @default.
- W2967149063 creator A5021562291 @default.
- W2967149063 creator A5028221691 @default.
- W2967149063 creator A5052166954 @default.
- W2967149063 creator A5055207647 @default.
- W2967149063 creator A5065973944 @default.
- W2967149063 date "2019-08-24" @default.
- W2967149063 modified "2023-10-14" @default.
- W2967149063 title "Cutaneous pharmacologic cAMP induction induces melanization of the skin and improves recovery from ultraviolet injury in melanocortin 1 receptor‐intact or heterozygous skin" @default.
- W2967149063 cites W1569256715 @default.
- W2967149063 cites W1600713198 @default.
- W2967149063 cites W1972341557 @default.
- W2967149063 cites W1979148478 @default.
- W2967149063 cites W1979580952 @default.
- W2967149063 cites W1981605211 @default.
- W2967149063 cites W1982527304 @default.
- W2967149063 cites W1995126053 @default.
- W2967149063 cites W2006809167 @default.
- W2967149063 cites W2025589989 @default.
- W2967149063 cites W2032368320 @default.
- W2967149063 cites W2037224878 @default.
- W2967149063 cites W2038180878 @default.
- W2967149063 cites W2051361428 @default.
- W2967149063 cites W2053991976 @default.
- W2967149063 cites W2054435056 @default.
- W2967149063 cites W2058633253 @default.
- W2967149063 cites W2067390087 @default.
- W2967149063 cites W2072506221 @default.
- W2967149063 cites W2081224298 @default.
- W2967149063 cites W2082823613 @default.
- W2967149063 cites W2089932023 @default.
- W2967149063 cites W2098465323 @default.
- W2967149063 cites W2109349283 @default.
- W2967149063 cites W2113638290 @default.
- W2967149063 cites W2131212622 @default.
- W2967149063 cites W2133821784 @default.
- W2967149063 cites W2137370771 @default.
- W2967149063 cites W2138759171 @default.
- W2967149063 cites W2154334152 @default.
- W2967149063 cites W2159875635 @default.
- W2967149063 cites W2162851671 @default.
- W2967149063 cites W2166030543 @default.
- W2967149063 cites W2170887950 @default.
- W2967149063 cites W2171020474 @default.
- W2967149063 cites W2220812108 @default.
- W2967149063 cites W2435708719 @default.
- W2967149063 cites W2474228978 @default.
- W2967149063 cites W2755981740 @default.
- W2967149063 cites W2795713411 @default.
- W2967149063 cites W2803358834 @default.
- W2967149063 cites W2911188335 @default.
- W2967149063 cites W2913324801 @default.
- W2967149063 cites W874929073 @default.
- W2967149063 doi "https://doi.org/10.1111/pcmr.12817" @default.
- W2967149063 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6928432" @default.
- W2967149063 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31398282" @default.
- W2967149063 hasPublicationYear "2019" @default.
- W2967149063 type Work @default.
- W2967149063 sameAs 2967149063 @default.
- W2967149063 citedByCount "10" @default.
- W2967149063 countsByYear W29671490632020 @default.
- W2967149063 countsByYear W29671490632021 @default.
- W2967149063 countsByYear W29671490632022 @default.
- W2967149063 countsByYear W29671490632023 @default.
- W2967149063 crossrefType "journal-article" @default.
- W2967149063 hasAuthorship W2967149063A5010983774 @default.
- W2967149063 hasAuthorship W2967149063A5018391981 @default.
- W2967149063 hasAuthorship W2967149063A5021562291 @default.
- W2967149063 hasAuthorship W2967149063A5028221691 @default.
- W2967149063 hasAuthorship W2967149063A5052166954 @default.
- W2967149063 hasAuthorship W2967149063A5055207647 @default.
- W2967149063 hasAuthorship W2967149063A5065973944 @default.
- W2967149063 hasBestOaLocation W29671490631 @default.
- W2967149063 hasConcept C104317684 @default.
- W2967149063 hasConcept C104451858 @default.
- W2967149063 hasConcept C107538193 @default.
- W2967149063 hasConcept C121608353 @default.
- W2967149063 hasConcept C127716648 @default.
- W2967149063 hasConcept C134018914 @default.
- W2967149063 hasConcept C143425029 @default.
- W2967149063 hasConcept C167975912 @default.
- W2967149063 hasConcept C170493617 @default.
- W2967149063 hasConcept C182843373 @default.
- W2967149063 hasConcept C2777459323 @default.
- W2967149063 hasConcept C2777658100 @default.
- W2967149063 hasConcept C2777789703 @default.
- W2967149063 hasConcept C2779276759 @default.
- W2967149063 hasConcept C2779769559 @default.
- W2967149063 hasConcept C2779993316 @default.
- W2967149063 hasConcept C502942594 @default.
- W2967149063 hasConcept C54355233 @default.
- W2967149063 hasConcept C552990157 @default.
- W2967149063 hasConcept C86803240 @default.
- W2967149063 hasConceptScore W2967149063C104317684 @default.
- W2967149063 hasConceptScore W2967149063C104451858 @default.