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• W2967152079 abstract "Background: Vancomycin pharmacokinetics are best described using a 2-compartment model. However, 1-compartment population models are commonly used as the basis for dose prediction software. Therefore, the validity of using a 1-compartment model to guide vancomycin drug dosing was examined. Methods: Published plasma concentration–time data from adult subjects (n = 30) with stable renal function administered a single intravenous infusion of vancomycin were extracted from previous studies. The vancomycin area under the curve (AUC 0–∞ ) was calculated for each subject using noncompartmental methods (AUC NCA ) and by fitting 1- (AUC 1CMT ), 2- (AUC 2CMT ), and 3- (AUC 3CMT ) compartment infusion models. The optimal model fit was determined using the Akaike information criterion and visual inspection of the residual plots. The individual compartmental AUC 0–∞ values from the 1- and 2-compartment models were compared with AUC NCA values using one-way repeated measures analysis of variance. Results: The mean (±SD) AUC estimates were similar for the different methods: AUC NCA 180 ± 86 mg·h/L, AUC 1CMT 167 ± 79 mg·h/L, and AUC 2CMT 183 ± 88 mg·h/L. Despite the overlapping AUC values, AUC 2CMT and AUC NCA were significantly greater than AUC 1CMT ( P < 0.05). The 3-compartment model was excluded from the analysis because of the failure to converge in some instances. Conclusions: Dose prediction software using a 1-compartment model as the basis for Bayesian forecasting underestimates drug exposure (estimated as the AUC) by less than 10%. This is unlikely to be clinically significant with respect to dose adjustment. Therefore, a 1-compartment model may be sufficient to guide vancomycin dosing in adult patients with stable renal function." @default.
• W2967152079 created "2019-08-22" @default.
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• W2967152079 date "2019-12-01" @default.
• W2967152079 modified "2023-10-17" @default.
• W2967152079 title "Comparison of the Area Under the Curve for Vancomycin Estimated Using Compartmental and Noncompartmental Methods in Adult Patients With Normal Renal Function" @default.
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• W2967152079 doi "https://doi.org/10.1097/ftd.0000000000000690" @default.
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