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• W2967176088 abstract "The functional annotation of genomes, including chromatin accessibility and modifications, is important for understanding and effectively utilizing the increased amount of genome sequences reported. However, while such annotation has been well explored in a diverse set of tissues and cell types in human and model organisms, relatively little data are available for livestock genomes, hindering our understanding of complex trait variation, domestication, and adaptive evolution. Here, we present the first complete global landscape of regulatory elements in cattle and explore the dynamics of chromatin states in rumen epithelial cells induced by the rumen developmental regulator—butyrate. We established the first global map of regulatory elements (15 chromatin states) and defined their coordinated activities in cattle, through genome-wide profiling for six histone modifications, RNA polymerase II, CTCF-binding sites, DNA accessibility, DNA methylation, and transcriptome in rumen epithelial primary cells (REPC), rumen tissues, and Madin-Darby bovine kidney epithelial cells (MDBK). We demonstrated that each chromatin state exhibited specific enrichment for sequence ontology, transcription, methylation, trait-associated variants, gene expression-associated variants, selection signatures, and evolutionarily conserved elements, implying distinct biological functions. After butyrate treatments, we observed that the weak enhancers and flanking active transcriptional start sites (TSS) were the most dynamic chromatin states, occurred concomitantly with significant alterations in gene expression and DNA methylation, which was significantly associated with heifer conception rate and stature economic traits. Our results demonstrate the crucial role of functional genome annotation for understanding genome regulation, complex trait variation, and adaptive evolution in livestock. Using butyrate to induce the dynamics of the epigenomic landscape, we were able to establish the correlation among nutritional elements, chromatin states, gene activities, and phenotypic outcomes." @default.
• W2967176088 created "2019-08-22" @default.
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• W2967176088 date "2019-08-16" @default.
• W2967176088 modified "2023-10-16" @default.
• W2967176088 title "Functional annotation of the cattle genome through systematic discovery and characterization of chromatin states and butyrate-induced variations" @default.
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• W2967176088 doi "https://doi.org/10.1186/s12915-019-0687-8" @default.
• W2967176088 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6698049" @default.
• W2967176088 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31419979" @default.
• W2967176088 hasPublicationYear "2019" @default.
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