Matches in SemOpenAlex for { <https://semopenalex.org/work/W2967204089> ?p ?o ?g. }
Showing items 1 to 97 of
97
with 100 items per page.
- W2967204089 abstract "Abstract BACKGROUND: Leptomeningeal carcinomatosis (LMC) is a complication of solid tumor malignancies where tumors metastasize to the leptomeninges. LMC complicates 4–15% of malignancies with incidence increasing as survival of patients with advanced cancer improves. Diagnostic methods include magnetic resonance imaging (MRI) and cerebrospinal fluid (CSF) cytology. We assessed detection methods, incidence, and outcomes of LMC at The Ohio State University Comprehensive Cancer Center from 2005–2015. METHODS: This was a single-institution retrospective study of 160 patients with confirmed diagnosis of LMC. Patients with hematologic and central nervous system malignancies were excluded. Descriptive statistics were used to summarize demographic and clinical characteristics. Overall survival (OS) was defined as time from LMC diagnosis to death or last known follow-up, and was generated using Kaplan-Meier methods. RESULTS: Median age of LMC diagnosis was 55.8 years (range: 48, 62.5). 69 (43%) patients had primary breast cancer, 41 (26%) had lung cancer, and 17 (11%) had melanoma. 73 patients (46%) presented with stage IV disease at initial diagnosis of the primary cancer, 41 (26%) with stage III disease, and 26 (16%) with stage II disease. Median time from diagnosis of primary cancer to diagnosis of LMC was 2 years (range: 0, 31.2). 158 (99%) patients had metastases at the time of LMC diagnosis, predominantly in bone (36%) or brain (36%). Median OS was 1.9 months (CI: 1.3, 2.5). 160 (100%) patients had an MRI of the brain or spine and 155 (97%) had MRI findings consistent with LMC. 75 (47%) patients underwent lumbar puncture, and 39 (52%) had CSF cytology positive for malignancy. CONCLUSIONS: Despite treatment, prognosis remains poor and confirmation of diagnosis can be challenging. This study highlights the need for novel therapeutics and improved diagnostic techniques for patients with LMC." @default.
- W2967204089 created "2019-08-22" @default.
- W2967204089 creator A5009849305 @default.
- W2967204089 creator A5030653735 @default.
- W2967204089 creator A5037535298 @default.
- W2967204089 creator A5039385718 @default.
- W2967204089 creator A5040916194 @default.
- W2967204089 creator A5049785882 @default.
- W2967204089 creator A5051842405 @default.
- W2967204089 creator A5060904459 @default.
- W2967204089 creator A5064885323 @default.
- W2967204089 creator A5067587535 @default.
- W2967204089 creator A5069711994 @default.
- W2967204089 creator A5080607677 @default.
- W2967204089 creator A5086903918 @default.
- W2967204089 creator A5087142771 @default.
- W2967204089 creator A5089937416 @default.
- W2967204089 date "2019-08-01" @default.
- W2967204089 modified "2023-09-27" @default.
- W2967204089 title "LPTO-10. ASSESSMENT OF LEPTOMENINGEAL CARCINOMATOSIS DIAGNOSIS AND OUTCOMES FROM 2005 TO 2015 AT THE OHIO STATE UNIVERSITY" @default.
- W2967204089 doi "https://doi.org/10.1093/noajnl/vdz014.033" @default.
- W2967204089 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7213376" @default.
- W2967204089 hasPublicationYear "2019" @default.
- W2967204089 type Work @default.
- W2967204089 sameAs 2967204089 @default.
- W2967204089 citedByCount "0" @default.
- W2967204089 crossrefType "journal-article" @default.
- W2967204089 hasAuthorship W2967204089A5009849305 @default.
- W2967204089 hasAuthorship W2967204089A5030653735 @default.
- W2967204089 hasAuthorship W2967204089A5037535298 @default.
- W2967204089 hasAuthorship W2967204089A5039385718 @default.
- W2967204089 hasAuthorship W2967204089A5040916194 @default.
- W2967204089 hasAuthorship W2967204089A5049785882 @default.
- W2967204089 hasAuthorship W2967204089A5051842405 @default.
- W2967204089 hasAuthorship W2967204089A5060904459 @default.
- W2967204089 hasAuthorship W2967204089A5064885323 @default.
- W2967204089 hasAuthorship W2967204089A5067587535 @default.
- W2967204089 hasAuthorship W2967204089A5069711994 @default.
- W2967204089 hasAuthorship W2967204089A5080607677 @default.
- W2967204089 hasAuthorship W2967204089A5086903918 @default.
- W2967204089 hasAuthorship W2967204089A5087142771 @default.
- W2967204089 hasAuthorship W2967204089A5089937416 @default.
- W2967204089 hasBestOaLocation W29672040891 @default.
- W2967204089 hasConcept C120665830 @default.
- W2967204089 hasConcept C121332964 @default.
- W2967204089 hasConcept C121608353 @default.
- W2967204089 hasConcept C126322002 @default.
- W2967204089 hasConcept C126838900 @default.
- W2967204089 hasConcept C141071460 @default.
- W2967204089 hasConcept C143409427 @default.
- W2967204089 hasConcept C146357865 @default.
- W2967204089 hasConcept C151730666 @default.
- W2967204089 hasConcept C167135981 @default.
- W2967204089 hasConcept C2776256026 @default.
- W2967204089 hasConcept C2778277180 @default.
- W2967204089 hasConcept C2779651940 @default.
- W2967204089 hasConcept C2910351856 @default.
- W2967204089 hasConcept C529278444 @default.
- W2967204089 hasConcept C61511704 @default.
- W2967204089 hasConcept C71924100 @default.
- W2967204089 hasConcept C86803240 @default.
- W2967204089 hasConceptScore W2967204089C120665830 @default.
- W2967204089 hasConceptScore W2967204089C121332964 @default.
- W2967204089 hasConceptScore W2967204089C121608353 @default.
- W2967204089 hasConceptScore W2967204089C126322002 @default.
- W2967204089 hasConceptScore W2967204089C126838900 @default.
- W2967204089 hasConceptScore W2967204089C141071460 @default.
- W2967204089 hasConceptScore W2967204089C143409427 @default.
- W2967204089 hasConceptScore W2967204089C146357865 @default.
- W2967204089 hasConceptScore W2967204089C151730666 @default.
- W2967204089 hasConceptScore W2967204089C167135981 @default.
- W2967204089 hasConceptScore W2967204089C2776256026 @default.
- W2967204089 hasConceptScore W2967204089C2778277180 @default.
- W2967204089 hasConceptScore W2967204089C2779651940 @default.
- W2967204089 hasConceptScore W2967204089C2910351856 @default.
- W2967204089 hasConceptScore W2967204089C529278444 @default.
- W2967204089 hasConceptScore W2967204089C61511704 @default.
- W2967204089 hasConceptScore W2967204089C71924100 @default.
- W2967204089 hasConceptScore W2967204089C86803240 @default.
- W2967204089 hasLocation W29672040891 @default.
- W2967204089 hasLocation W29672040892 @default.
- W2967204089 hasOpenAccess W2967204089 @default.
- W2967204089 hasPrimaryLocation W29672040891 @default.
- W2967204089 hasRelatedWork W10076782 @default.
- W2967204089 hasRelatedWork W12586970 @default.
- W2967204089 hasRelatedWork W13023206 @default.
- W2967204089 hasRelatedWork W3386595 @default.
- W2967204089 hasRelatedWork W5061419 @default.
- W2967204089 hasRelatedWork W7997555 @default.
- W2967204089 hasRelatedWork W8971983 @default.
- W2967204089 hasRelatedWork W9441211 @default.
- W2967204089 hasRelatedWork W17759843 @default.
- W2967204089 hasRelatedWork W8549601 @default.
- W2967204089 isParatext "false" @default.
- W2967204089 isRetracted "false" @default.
- W2967204089 magId "2967204089" @default.
- W2967204089 workType "article" @default.