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• W2967207579 endingPage "115047" @default.
• W2967207579 startingPage "115047" @default.
• W2967207579 abstract "A series of N-substituted (Z)-2-imino-(5Z)-ylidene thiazolidines/thiazolidin-4-ones were synthesized and their antiproliferative activities against colon (HCT-116) and breast (MCF7) cancer cell lines were evaluated utilizing an MTT growth assay. A 2D-QSAR investigation was conducted to probe and validate the obtained antiproliferative properties for the thiazolidine derivatives. The majority of the thiazolidines exhibit higher potency against a colon cancer cell line relative to the standard reference. The p-halophenylimino p-anisylidene derivatives exhibited the highest anti-proliferative activity against HCT116 relative to control (IC50 = 8.9-10.0 μM compared to 20.4 μM observed for 5-fluorouracil as positive control). An X-ray study confirmed the Z, Z'-configurations for two examples of the synthesized compounds." @default.
• W2967207579 created "2019-08-22" @default.
• W2967207579 creator A5031053900 @default.
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• W2967207579 date "2019-10-01" @default.
• W2967207579 modified "2023-10-17" @default.
• W2967207579 title "Novel thiazolidines: Synthesis, antiproliferative properties and 2D-QSAR studies" @default.
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• W2967207579 doi "https://doi.org/10.1016/j.bmc.2019.115047" @default.
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