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- W2967210895 endingPage "2182" @default.
- W2967210895 startingPage "2165" @default.
- W2967210895 abstract "Transfecting nucleic acids into cells is an essential procedure in biological research usually performed using nonviral transfection reagents. Unfortunately, most transfection reagents have polymeric or undisclosed structures and require nonstandard synthetic procedures. Herein we report peptide dendrimers accessible as pure products from standard building blocks by solid-phase peptide synthesis and acting as nontoxic single component siRNA transfection reagents for a variety of cell lines with equal or better performance than the gold standard lipofectamine L2000. Structure-activity relationships and mechanistic studies illuminate their transfection mechanism in unprecedented detail. Stereoselective dendrimer aggregation via intermolecular β-sheets at neutral pH enables siRNA complexation to form nanoparticles which enter cells by endocytosis. Endosome acidification triggers protonation of amino termini and rearrangement to an α-helical conformation forming smaller dendrimer/siRNA nanoparticles, which escape the endosome and release their siRNA cargo in the cytosol. Two particularly efficient d-enantiomeric dendrimers are proposed as new reference reagents for siRNA transfection." @default.
- W2967210895 created "2019-08-22" @default.
- W2967210895 creator A5004050775 @default.
- W2967210895 creator A5040229188 @default.
- W2967210895 creator A5040848839 @default.
- W2967210895 creator A5041612815 @default.
- W2967210895 date "2019-08-09" @default.
- W2967210895 modified "2023-09-29" @default.
- W2967210895 title "Stereoselective pH Responsive Peptide Dendrimers for siRNA Transfection" @default.
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- W2967210895 doi "https://doi.org/10.1021/acs.bioconjchem.9b00403" @default.
- W2967210895 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31398014" @default.
- W2967210895 hasPublicationYear "2019" @default.