FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2967211009> ?p ?o ?g. }

• W2967211009 endingPage "14382" @default.
• W2967211009 startingPage "14370" @default.
• W2967211009 abstract "A critical step in the development of chronic inflammatory diseases is the accumulation of proinflammatory macrophages in the extracellular matrix (ECM) of peripheral tissues. The adhesion receptor integrin αDβ2 promotes the development of atherosclerosis and diabetes by supporting macrophage retention in inflamed tissue. We recently found that the end product of docosahexaenoic acid (DHA) oxidation, 2-(ω-carboxyethyl)pyrrole (CEP), serves as a ligand for αDβ2. CEP adduct with ECM is generated during inflammation-mediated lipid peroxidation. The goal of this project was to identify a specific inhibitor for αDβ2–CEP interaction that can prevent macrophage accumulation. Using a specially designed peptide library, Biacore-detected protein–protein interaction, and adhesion of integrin-transfected HEK 293 cells, we identified a sequence (called P5 peptide) that significantly and specifically inhibited αD–CEP binding. In the model of thioglycollate-induced peritoneal inflammation, the injection of cyclic P5 peptide reduced 3-fold the macrophage accumulation in WT mice but had no effect in αD-deficient mice. The tracking of adoptively transferred, fluorescently labeled WT and αD−/− monocytes in the model of peritoneal inflammation and in vitro two-dimensional and three-dimensional migration assays demonstrated that P5 peptide does not affect monocyte transendothelial migration or macrophage efflux from the peritoneal cavity but regulates macrophage migration through the ECM. Moreover, the injection of P5 peptide into WT mice on a high-fat diet prevents macrophage accumulation in adipose tissue in an αDβ2-dependent manner. Taken together, these results demonstrate the importance of αDβ2-mediated macrophage adhesion for the accumulation of infiltrating macrophages in the inflamed ECM and propose P5 peptide as a potential inhibitor of atherogenesis and diabetes." @default.
• W2967211009 created "2019-08-22" @default.
• W2967211009 creator A5026185298 @default.
• W2967211009 creator A5043277346 @default.
• W2967211009 creator A5043856723 @default.
• W2967211009 creator A5052505308 @default.
• W2967211009 creator A5061722103 @default.
• W2967211009 creator A5080274586 @default.
• W2967211009 creator A5082188638 @default.
• W2967211009 date "2019-09-01" @default.
• W2967211009 modified "2023-10-15" @default.
• W2967211009 title "Inhibition of integrin αDβ2–mediated macrophage adhesion to end product of docosahexaenoic acid (DHA) oxidation prevents macrophage accumulation during inflammation" @default.
• W2967211009 cites W1491280754 @default.
• W2967211009 cites W1514135676 @default.
• W2967211009 cites W1970221521 @default.
• W2967211009 cites W1971479269 @default.
• W2967211009 cites W1978418704 @default.
• W2967211009 cites W1981571305 @default.
• W2967211009 cites W1985235161 @default.
• W2967211009 cites W1993312924 @default.
• W2967211009 cites W1996283676 @default.
• W2967211009 cites W1999753882 @default.
• W2967211009 cites W2001774963 @default.
• W2967211009 cites W2009592273 @default.
• W2967211009 cites W2016916867 @default.
• W2967211009 cites W2017376731 @default.
• W2967211009 cites W2024111238 @default.
• W2967211009 cites W2028575077 @default.
• W2967211009 cites W2028994197 @default.
• W2967211009 cites W2030611470 @default.
• W2967211009 cites W2035538295 @default.
• W2967211009 cites W2036760345 @default.
• W2967211009 cites W2045149132 @default.
• W2967211009 cites W2071629691 @default.
• W2967211009 cites W2081087447 @default.
• W2967211009 cites W2103601941 @default.
• W2967211009 cites W2104771513 @default.
• W2967211009 cites W2107760385 @default.
• W2967211009 cites W2109420700 @default.
• W2967211009 cites W2110981204 @default.
• W2967211009 cites W2129098607 @default.
• W2967211009 cites W2134669670 @default.
• W2967211009 cites W2137963069 @default.
• W2967211009 cites W2145740221 @default.
• W2967211009 cites W2171782802 @default.
• W2967211009 cites W2317628705 @default.
• W2967211009 cites W2335432651 @default.
• W2967211009 cites W2439008136 @default.
• W2967211009 cites W2534034261 @default.
• W2967211009 cites W2552480958 @default.
• W2967211009 cites W2598112362 @default.
• W2967211009 cites W2613498736 @default.
• W2967211009 cites W2619739951 @default.
• W2967211009 cites W2778876317 @default.
• W2967211009 cites W2789228629 @default.
• W2967211009 cites W2799310615 @default.
• W2967211009 cites W2802586307 @default.
• W2967211009 cites W2901831700 @default.
• W2967211009 doi "https://doi.org/10.1074/jbc.ra119.009590" @default.
• W2967211009 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6768641" @default.
• W2967211009 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31395659" @default.
• W2967211009 hasPublicationYear "2019" @default.
• W2967211009 type Work @default.
• W2967211009 sameAs 2967211009 @default.
• W2967211009 citedByCount "11" @default.
• W2967211009 countsByYear W29672110092020 @default.
• W2967211009 countsByYear W29672110092021 @default.
• W2967211009 countsByYear W29672110092022 @default.
• W2967211009 countsByYear W29672110092023 @default.
• W2967211009 crossrefType "journal-article" @default.
• W2967211009 hasAuthorship W2967211009A5026185298 @default.
• W2967211009 hasAuthorship W2967211009A5043277346 @default.
• W2967211009 hasAuthorship W2967211009A5043856723 @default.
• W2967211009 hasAuthorship W2967211009A5052505308 @default.
• W2967211009 hasAuthorship W2967211009A5061722103 @default.
• W2967211009 hasAuthorship W2967211009A5080274586 @default.
• W2967211009 hasAuthorship W2967211009A5082188638 @default.
• W2967211009 hasBestOaLocation W29672110091 @default.
• W2967211009 hasConcept C1491633281 @default.
• W2967211009 hasConcept C178790620 @default.
• W2967211009 hasConcept C185592680 @default.
• W2967211009 hasConcept C19038510 @default.
• W2967211009 hasConcept C195687474 @default.
• W2967211009 hasConcept C202751555 @default.
• W2967211009 hasConcept C203014093 @default.
• W2967211009 hasConcept C2776914184 @default.
• W2967211009 hasConcept C2777171753 @default.
• W2967211009 hasConcept C2779244956 @default.
• W2967211009 hasConcept C543025807 @default.
• W2967211009 hasConcept C55493867 @default.
• W2967211009 hasConcept C84416704 @default.
• W2967211009 hasConcept C85789140 @default.
• W2967211009 hasConcept C86803240 @default.
• W2967211009 hasConcept C95444343 @default.
• W2967211009 hasConceptScore W2967211009C1491633281 @default.
• W2967211009 hasConceptScore W2967211009C178790620 @default.
• W2967211009 hasConceptScore W2967211009C185592680 @default.
• W2967211009 hasConceptScore W2967211009C19038510 @default.

• next