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- W2967221224 endingPage "1941" @default.
- W2967221224 startingPage "1941" @default.
- W2967221224 abstract "Growth hormone (GH) and glutamine (Gln) stimulate the growth of the intestinal mucosa. GH activates the proliferation of intestinal stem cells (ISCs), enhances the formation of crypt organoids, increases ISC stemness markers in the intestinal organoids, and drives the differentiation of ISCs into Paneth cells and enterocytes. Gln enhances the proliferation of ISCs and increases crypt organoid formation; however, it mainly acts on the post-proliferation activity of ISCs to maintain the stability of crypt organoids and the intestinal mucosa, as well as to stimulate the differentiation of ISCs into goblet cells and possibly Paneth cells and enteroendocrine cells. Since GH and Gln have differential effects on ISCs. Their use in combination may have synergistic effects on ISCs. In this review, we summarize the evidence of the actions of GH and/or Gln on crypt cells and ISCs in the literature. Overall, most studies demonstrated that GH and Gln in combination exerted synergistic effects to activate the proliferation of crypt cells and ISCs and enhance crypt organoid formation and mucosal growth. This treatment influenced the proliferation of ISCs to a similar degree as GH treatment alone and the differentiation of ISCs to a similar degree as Gln treatment alone." @default.
- W2967221224 created "2019-08-22" @default.
- W2967221224 creator A5005983391 @default.
- W2967221224 creator A5006744517 @default.
- W2967221224 creator A5061402622 @default.
- W2967221224 creator A5076752267 @default.
- W2967221224 date "2019-08-17" @default.
- W2967221224 modified "2023-09-26" @default.
- W2967221224 title "Influence of Growth Hormone and Glutamine on Intestinal Stem Cells: A Narrative Review" @default.
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