FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2967245735> ?p ?o ?g. }

• W2967245735 endingPage "205435811986799" @default.
• W2967245735 startingPage "205435811986799" @default.
• W2967245735 abstract "Background: Prevalence of immunosuppressant nonadherence in renal transplant recipients is high despite negative clinical outcomes associated with nonadherence. Simplification of dosing has been demonstrated to improve adherence in renal transplant recipients as measured through electronic monitoring and self-report. Objective: The purpose of this study was to replicate and extend previous findings by measuring adherence with multiple methods in a Canadian sample. Design: The study design was a randomized controlled medication dosing trial in adult renal transplant patients. The trial length was 4 months. Setting: This study was conducted within the Solid Organ Transplant (SOT) Clinic at Vancouver General Hospital (VGH; Vancouver, Canada). Patients: A total of 46 adult renal recipients (at least 1 year post-transplant) were recruited through the SOT clinic. With 8 withdrawals, 38 individuals completed all phases of the study. Measurements: Medication adherence was measured for a period of 4 months using multiple methods, including electronic monitoring (MEMS [Medication Event Monitoring System]), pharmacy refill data (medication possession ratio [MPR]), and by self-report using the Adherence subscale of the Transplant Effects Questionnaire (TEQ). Methods: Participants were randomized to twice-daily (n = 19) or once-daily tacrolimus dosing (n = 19) and followed over a 4-month period via monthly clinic study visits. Comparisons between the treatment groups were performed using the Mann-Whitney U and chi-square tests, for continuous and categorical variables, respectively. Results: As outlined in Table 3, the once-daily dosing group showed significantly better MEMS Dose Adherence ( P = .001), whereas MEMS Timing Adherence showed a tendency toward better adherence for this group, but was not significant ( P = .052). MEMS Days Adherent ( P = .418), MPR% ( P = .123), and self-reported adherence ( P = .284) did not differ between the once- and twice-daily dosing groups when measured as continuous variables. The MPR% was significantly better for the once-daily dosing group when measured dichotomously but not continuously ( P = .044). Notably, most of those exposed to once-daily dosing (63.2%) preferred this to the twice-daily regimen. Limitations: Limitations included small sample size and short follow-up period, precluding the examination of clinical outcome differences. Conclusions: Results for dose adherence replicate the finding that dose simplification increases adherence to immunosuppressants as measured through electronic monitoring. Such an advantage for the once-daily dosing group was not seen across the 2 other electronic monitoring measurement variables (days and timing adherence). This study extends previous research by examining adherence in once versus twice-daily dosing via prescription refill data in a Canadian sample. Given the gravity of potential health outcomes associated with nonadherence, although results indicate inconsistencies in significance testing across measurement methods, the medium to large effect sizes seen in the data favoring better adherence with once-daily dosing provide an indication of the potential clinical significance of these findings. Trial registration: This study was registered with ClinicalTrials.gov (NCT01334333) on April 11, 2011." @default.
• W2967245735 created "2019-08-22" @default.
• W2967245735 creator A5000099954 @default.
• W2967245735 creator A5032778782 @default.
• W2967245735 creator A5069282517 @default.
• W2967245735 creator A5069670566 @default.
• W2967245735 date "2019-01-01" @default.
• W2967245735 modified "2023-10-16" @default.
• W2967245735 title "Impact of Once- Versus Twice-Daily Tacrolimus Dosing on Medication Adherence in Stable Renal Transplant Recipients: A Canadian Single-Center Randomized Controlled Trial" @default.
• W2967245735 cites W107676761 @default.
• W2967245735 cites W1741567663 @default.
• W2967245735 cites W1964040862 @default.
• W2967245735 cites W1983872259 @default.
• W2967245735 cites W1988930537 @default.
• W2967245735 cites W1994537204 @default.
• W2967245735 cites W2006769125 @default.
• W2967245735 cites W2019290108 @default.
• W2967245735 cites W2024823143 @default.
• W2967245735 cites W2037557484 @default.
• W2967245735 cites W2061348766 @default.
• W2967245735 cites W2063465629 @default.
• W2967245735 cites W2063825733 @default.
• W2967245735 cites W2069947800 @default.
• W2967245735 cites W2072372268 @default.
• W2967245735 cites W2090481644 @default.
• W2967245735 cites W2101135014 @default.
• W2967245735 cites W2117900547 @default.
• W2967245735 cites W2119124227 @default.
• W2967245735 cites W2129751987 @default.
• W2967245735 cites W2134893798 @default.
• W2967245735 cites W2139132912 @default.
• W2967245735 cites W2149303024 @default.
• W2967245735 cites W2151433573 @default.
• W2967245735 cites W2153774782 @default.
• W2967245735 cites W2277002051 @default.
• W2967245735 cites W2344032891 @default.
• W2967245735 cites W2518045192 @default.
• W2967245735 cites W4243177274 @default.
• W2967245735 doi "https://doi.org/10.1177/2054358119867993" @default.
• W2967245735 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6699008" @default.
• W2967245735 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31452902" @default.
• W2967245735 hasPublicationYear "2019" @default.
• W2967245735 type Work @default.
• W2967245735 sameAs 2967245735 @default.
• W2967245735 citedByCount "9" @default.
• W2967245735 countsByYear W29672457352020 @default.
• W2967245735 countsByYear W29672457352021 @default.
• W2967245735 countsByYear W29672457352022 @default.
• W2967245735 countsByYear W29672457352023 @default.
• W2967245735 crossrefType "journal-article" @default.
• W2967245735 hasAuthorship W2967245735A5000099954 @default.
• W2967245735 hasAuthorship W2967245735A5032778782 @default.
• W2967245735 hasAuthorship W2967245735A5069282517 @default.
• W2967245735 hasAuthorship W2967245735A5069670566 @default.
• W2967245735 hasBestOaLocation W29672457351 @default.
• W2967245735 hasConcept C104863432 @default.
• W2967245735 hasConcept C126322002 @default.
• W2967245735 hasConcept C168563851 @default.
• W2967245735 hasConcept C194828623 @default.
• W2967245735 hasConcept C2777288759 @default.
• W2967245735 hasConcept C2780303639 @default.
• W2967245735 hasConcept C2909675724 @default.
• W2967245735 hasConcept C2911091166 @default.
• W2967245735 hasConcept C2992666275 @default.
• W2967245735 hasConcept C512399662 @default.
• W2967245735 hasConcept C535046627 @default.
• W2967245735 hasConcept C71924100 @default.
• W2967245735 hasConceptScore W2967245735C104863432 @default.
• W2967245735 hasConceptScore W2967245735C126322002 @default.
• W2967245735 hasConceptScore W2967245735C168563851 @default.
• W2967245735 hasConceptScore W2967245735C194828623 @default.
• W2967245735 hasConceptScore W2967245735C2777288759 @default.
• W2967245735 hasConceptScore W2967245735C2780303639 @default.
• W2967245735 hasConceptScore W2967245735C2909675724 @default.
• W2967245735 hasConceptScore W2967245735C2911091166 @default.
• W2967245735 hasConceptScore W2967245735C2992666275 @default.
• W2967245735 hasConceptScore W2967245735C512399662 @default.
• W2967245735 hasConceptScore W2967245735C535046627 @default.
• W2967245735 hasConceptScore W2967245735C71924100 @default.
• W2967245735 hasFunder F4320313447 @default.
• W2967245735 hasFunder F4320319947 @default.
• W2967245735 hasFunder F4320319965 @default.
• W2967245735 hasLocation W29672457351 @default.
• W2967245735 hasLocation W29672457352 @default.
• W2967245735 hasLocation W29672457353 @default.
• W2967245735 hasLocation W29672457354 @default.
• W2967245735 hasLocation W29672457355 @default.
• W2967245735 hasLocation W29672457356 @default.
• W2967245735 hasOpenAccess W2967245735 @default.
• W2967245735 hasPrimaryLocation W29672457351 @default.
• W2967245735 hasRelatedWork W1986708285 @default.
• W2967245735 hasRelatedWork W2000836995 @default.
• W2967245735 hasRelatedWork W2034728660 @default.
• W2967245735 hasRelatedWork W2116212001 @default.
• W2967245735 hasRelatedWork W2316546509 @default.
• W2967245735 hasRelatedWork W2370117545 @default.
• W2967245735 hasRelatedWork W2389946526 @default.
• W2967245735 hasRelatedWork W2884108184 @default.

• next