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- W2967264711 abstract "Abstract Cytochrome P450 monooxygenases (P450s) are ubiquitous hemeproteins that insert oxygen specifically into substrates leading to diverse chemical transformations. Utilizing their capabilities, microbial whole‐cell biocatalysts are applied in pharmaceutical and fine chemical industry to produce biomolecules and drug metabolites. In order to synthesize novel bioactive compounds there is a great demand to identify P450s with new reaction and substrate scope. In this study, genome mining and an activity screening were successfully combined to discover so far underutilized biocatalysts. The screening revealed the expected broad range of reactions, such as hydroxylations, dealkylations, reductions and desaturations. For Actinosynnema mirum and ritonavir the biotransformation was transferred to a preparative scale resulting in a ritonavir conversion of 90 % after 48 h and 13 different metabolites analyzed by LC‐MS 2 and NMR. These results clearly demonstrate the potential of the underlying approach to identify promising whole cell biocatalysts with good conversion and product scopes." @default.
- W2967264711 created "2019-08-22" @default.
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- W2967264711 date "2019-09-12" @default.
- W2967264711 modified "2023-09-30" @default.
- W2967264711 title "Accessing the Biocatalytic Potential for C−H‐Activation by Targeted Genome Mining and Screening" @default.
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- W2967264711 doi "https://doi.org/10.1002/cctc.201901273" @default.
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