FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2967274089> ?p ?o ?g. }

• W2967274089 endingPage "1961" @default.
• W2967274089 startingPage "1952" @default.
• W2967274089 abstract "Abstract This study aims to investigate the role of long noncoding RNA SNHG20 in the progression of nonalcoholic fatty liver disease (NALFD) to hepatocellular carcinoma (HCC), and to elucidate whether polarization of Kupffer cells (KCs, liver macrophages) was involved in this process. Mouse NALFD was induced by 16 weeks of high‐fat diet (HFD) feeding. Mouse NALFD‐HCC was induced by 36 weeks of HFD feeding (from 1 week to 36 weeks) and 20 weeks of diethyl nitrosamine (DEN) administration (from 17 weeks to 36 weeks). The LV‐shRNA‐ and LV‐sh‐SNHG20‐infected RAW264.7 cells were injected into the NALFD mice followed by DEN treatment to evaluate the role of SNHG20 in regulating the progression of NALFD to HCC in mice. The proportion of M1 and M2 macrophages was determined by flow cytometry. The levels of M1‐related inducible nitric oxide synthase (iNOS) and tumor necrosis factor‐α and M2‐related Arg‐1 and interleukin (IL)‐10 were also examined. SNHG20 expression was decreased in NALFD but increased in NALFD‐HCC, both in human and experimental mouse livers. Furthermore, human and mouse NALFD‐HCC KCs displayed decreased M1/M2 ratio compared with NALFD KCs. Moreover, SNHG20 overexpression induced M2 polarization through activating STAT6, whereas SNHG20 silencing suppressed M1 polarization in RAW264.7 macrophages and delayed the progression of NALFD to HCC in mice. SNHG20 may facilitate the progression of NALFD to HCC via inducing liver KCs M2 polarization via STAT6 activation." @default.
• W2967274089 created "2019-08-22" @default.
• W2967274089 creator A5006625246 @default.
• W2967274089 creator A5013991228 @default.
• W2967274089 creator A5040101334 @default.
• W2967274089 creator A5045262728 @default.
• W2967274089 creator A5067782844 @default.
• W2967274089 date "2019-08-13" @default.
• W2967274089 modified "2023-10-02" @default.
• W2967274089 title "Silencing of lncRNA SNHG20 delays the progression of nonalcoholic fatty liver disease to hepatocellular carcinoma via regulating liver Kupffer cells polarization" @default.
• W2967274089 cites W2003273586 @default.
• W2967274089 cites W2032234779 @default.
• W2967274089 cites W2042207589 @default.
• W2967274089 cites W2094017811 @default.
• W2967274089 cites W2096147603 @default.
• W2967274089 cites W2106027870 @default.
• W2967274089 cites W2135400708 @default.
• W2967274089 cites W2161111868 @default.
• W2967274089 cites W2288325680 @default.
• W2967274089 cites W2399153906 @default.
• W2967274089 cites W2515730340 @default.
• W2967274089 cites W2561860468 @default.
• W2967274089 cites W2588823181 @default.
• W2967274089 cites W2594856766 @default.
• W2967274089 cites W2724583681 @default.
• W2967274089 cites W2747000876 @default.
• W2967274089 cites W2763759608 @default.
• W2967274089 cites W2789893847 @default.
• W2967274089 cites W2795563988 @default.
• W2967274089 cites W2807114165 @default.
• W2967274089 cites W2883519846 @default.
• W2967274089 cites W2903801101 @default.
• W2967274089 cites W2910875000 @default.
• W2967274089 cites W2912868975 @default.
• W2967274089 cites W2917837889 @default.
• W2967274089 cites W2950360778 @default.
• W2967274089 doi "https://doi.org/10.1002/iub.2137" @default.
• W2967274089 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31408278" @default.
• W2967274089 hasPublicationYear "2019" @default.
• W2967274089 type Work @default.
• W2967274089 sameAs 2967274089 @default.
• W2967274089 citedByCount "28" @default.
• W2967274089 countsByYear W29672740892020 @default.
• W2967274089 countsByYear W29672740892021 @default.
• W2967274089 countsByYear W29672740892022 @default.
• W2967274089 countsByYear W29672740892023 @default.
• W2967274089 crossrefType "journal-article" @default.
• W2967274089 hasAuthorship W2967274089A5006625246 @default.
• W2967274089 hasAuthorship W2967274089A5013991228 @default.
• W2967274089 hasAuthorship W2967274089A5040101334 @default.
• W2967274089 hasAuthorship W2967274089A5045262728 @default.
• W2967274089 hasAuthorship W2967274089A5067782844 @default.
• W2967274089 hasBestOaLocation W29672740891 @default.
• W2967274089 hasConcept C104317684 @default.
• W2967274089 hasConcept C119056186 @default.
• W2967274089 hasConcept C126322002 @default.
• W2967274089 hasConcept C134018914 @default.
• W2967274089 hasConcept C173396325 @default.
• W2967274089 hasConcept C17991360 @default.
• W2967274089 hasConcept C190232843 @default.
• W2967274089 hasConcept C190283241 @default.
• W2967274089 hasConcept C22615655 @default.
• W2967274089 hasConcept C2776637226 @default.
• W2967274089 hasConcept C2776954865 @default.
• W2967274089 hasConcept C2778019345 @default.
• W2967274089 hasConcept C2778772119 @default.
• W2967274089 hasConcept C2779134260 @default.
• W2967274089 hasConcept C502942594 @default.
• W2967274089 hasConcept C55493867 @default.
• W2967274089 hasConcept C67705224 @default.
• W2967274089 hasConcept C71924100 @default.
• W2967274089 hasConcept C86803240 @default.
• W2967274089 hasConceptScore W2967274089C104317684 @default.
• W2967274089 hasConceptScore W2967274089C119056186 @default.
• W2967274089 hasConceptScore W2967274089C126322002 @default.
• W2967274089 hasConceptScore W2967274089C134018914 @default.
• W2967274089 hasConceptScore W2967274089C173396325 @default.
• W2967274089 hasConceptScore W2967274089C17991360 @default.
• W2967274089 hasConceptScore W2967274089C190232843 @default.
• W2967274089 hasConceptScore W2967274089C190283241 @default.
• W2967274089 hasConceptScore W2967274089C22615655 @default.
• W2967274089 hasConceptScore W2967274089C2776637226 @default.
• W2967274089 hasConceptScore W2967274089C2776954865 @default.
• W2967274089 hasConceptScore W2967274089C2778019345 @default.
• W2967274089 hasConceptScore W2967274089C2778772119 @default.
• W2967274089 hasConceptScore W2967274089C2779134260 @default.
• W2967274089 hasConceptScore W2967274089C502942594 @default.
• W2967274089 hasConceptScore W2967274089C55493867 @default.
• W2967274089 hasConceptScore W2967274089C67705224 @default.
• W2967274089 hasConceptScore W2967274089C71924100 @default.
• W2967274089 hasConceptScore W2967274089C86803240 @default.
• W2967274089 hasIssue "12" @default.
• W2967274089 hasLocation W29672740891 @default.
• W2967274089 hasLocation W29672740892 @default.
• W2967274089 hasOpenAccess W2967274089 @default.
• W2967274089 hasPrimaryLocation W29672740891 @default.
• W2967274089 hasRelatedWork W1973843004 @default.
• W2967274089 hasRelatedWork W1977918131 @default.

• next