Matches in SemOpenAlex for { <https://semopenalex.org/work/W2967299390> ?p ?o ?g. }
- W2967299390 endingPage "109501" @default.
- W2967299390 startingPage "109501" @default.
- W2967299390 abstract "17α-ethynylestradiol (EE2), a ubiquitous synthetic endocrine disrupting chemical, was the principal component of contraceptive drugs and one of common hormone medications. The detrimental impact of EE2 on the reproduction of organisms was widely recognized. However, the underlying mechanisms of physiological and metabolome effects of EE2 on freshwater fish are still unclear. This study investigated the toxic effects and related mechanisms of EE2 on freshwater fish crucian carp (Carassius auratus) based on metabolomics. Crucian carp were exposed to EE2 at environmentally relevant concentration for 9 days, 18 days, and 27 days, and the biological responses were explored through analysis of the physiological endpoints, steroid hormones, and metabolome. The physiological endpoints of crucian carp had no distinct change after EE2 exposure. However, metabolomics analysis probed significant deviation based on chemometrics, indicating that the metabolomics approach was more sensitive to the effects of EE2 at environmentally relevant concentration to freshwater fish than the traditional endpoints. The alterations of 24 metabolites in gonad and 16 metabolites in kidney were induced by treatment with EE2, respectively, which suggesting the perturbations in amino acid metabolism, lipid metabolism, energy metabolism, and oxidative stress. Moreover, EE2 exposure could induce the disruption of lipid metabolism and then broke the homeostasis of endogenous steroid hormones. Metabolomics provided a new strategy for the studies on contaminant exposure at a low dose in the short term and gave important information for the toxicology and mechanism of EE2." @default.
- W2967299390 created "2019-08-22" @default.
- W2967299390 creator A5014411298 @default.
- W2967299390 creator A5027605982 @default.
- W2967299390 creator A5044367029 @default.
- W2967299390 creator A5061436150 @default.
- W2967299390 creator A5065534113 @default.
- W2967299390 date "2019-11-01" @default.
- W2967299390 modified "2023-10-14" @default.
- W2967299390 title "Responses in the crucian carp (Carassius auratus) exposed to environmentally relevant concentration of 17α-Ethinylestradiol based on metabolomics" @default.
- W2967299390 cites W1529592271 @default.
- W2967299390 cites W1581878040 @default.
- W2967299390 cites W1649850638 @default.
- W2967299390 cites W1967518465 @default.
- W2967299390 cites W1970427647 @default.
- W2967299390 cites W1977169176 @default.
- W2967299390 cites W1986541184 @default.
- W2967299390 cites W1994324019 @default.
- W2967299390 cites W2002583208 @default.
- W2967299390 cites W2002923761 @default.
- W2967299390 cites W2004791998 @default.
- W2967299390 cites W2009315200 @default.
- W2967299390 cites W2012960069 @default.
- W2967299390 cites W2026205682 @default.
- W2967299390 cites W2027575018 @default.
- W2967299390 cites W2034873249 @default.
- W2967299390 cites W2036425104 @default.
- W2967299390 cites W2039716282 @default.
- W2967299390 cites W2042161399 @default.
- W2967299390 cites W2042668625 @default.
- W2967299390 cites W2054369476 @default.
- W2967299390 cites W2055569908 @default.
- W2967299390 cites W2056907461 @default.
- W2967299390 cites W2059174999 @default.
- W2967299390 cites W2060738997 @default.
- W2967299390 cites W2063028213 @default.
- W2967299390 cites W2078064450 @default.
- W2967299390 cites W2082088176 @default.
- W2967299390 cites W2084015464 @default.
- W2967299390 cites W2095390308 @default.
- W2967299390 cites W2111038162 @default.
- W2967299390 cites W2120350838 @default.
- W2967299390 cites W2123617287 @default.
- W2967299390 cites W2157550331 @default.
- W2967299390 cites W2169412126 @default.
- W2967299390 cites W2280989133 @default.
- W2967299390 cites W2316744180 @default.
- W2967299390 cites W2323169894 @default.
- W2967299390 cites W2346401048 @default.
- W2967299390 cites W2402187452 @default.
- W2967299390 cites W2515558325 @default.
- W2967299390 cites W2516507226 @default.
- W2967299390 cites W2516771479 @default.
- W2967299390 cites W2530831221 @default.
- W2967299390 cites W2544368925 @default.
- W2967299390 cites W2546396707 @default.
- W2967299390 cites W2555227791 @default.
- W2967299390 cites W2560339773 @default.
- W2967299390 cites W2593126656 @default.
- W2967299390 cites W2593853578 @default.
- W2967299390 cites W2597779728 @default.
- W2967299390 cites W2612424443 @default.
- W2967299390 cites W2772259795 @default.
- W2967299390 cites W2777699512 @default.
- W2967299390 cites W2781502673 @default.
- W2967299390 cites W2804747821 @default.
- W2967299390 cites W2885525061 @default.
- W2967299390 cites W2895855502 @default.
- W2967299390 cites W2922750735 @default.
- W2967299390 cites W2923029396 @default.
- W2967299390 cites W2944307309 @default.
- W2967299390 cites W618285676 @default.
- W2967299390 doi "https://doi.org/10.1016/j.ecoenv.2019.109501" @default.
- W2967299390 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31401330" @default.
- W2967299390 hasPublicationYear "2019" @default.
- W2967299390 type Work @default.
- W2967299390 sameAs 2967299390 @default.
- W2967299390 citedByCount "20" @default.
- W2967299390 countsByYear W29672993902020 @default.
- W2967299390 countsByYear W29672993902021 @default.
- W2967299390 countsByYear W29672993902022 @default.
- W2967299390 countsByYear W29672993902023 @default.
- W2967299390 crossrefType "journal-article" @default.
- W2967299390 hasAuthorship W2967299390A5014411298 @default.
- W2967299390 hasAuthorship W2967299390A5027605982 @default.
- W2967299390 hasAuthorship W2967299390A5044367029 @default.
- W2967299390 hasAuthorship W2967299390A5061436150 @default.
- W2967299390 hasAuthorship W2967299390A5065534113 @default.
- W2967299390 hasConcept C134018914 @default.
- W2967299390 hasConcept C135870905 @default.
- W2967299390 hasConcept C21565614 @default.
- W2967299390 hasConcept C2777142705 @default.
- W2967299390 hasConcept C2780862370 @default.
- W2967299390 hasConcept C2781471917 @default.
- W2967299390 hasConcept C2909208804 @default.
- W2967299390 hasConcept C46699223 @default.
- W2967299390 hasConcept C505870484 @default.
- W2967299390 hasConcept C60644358 @default.