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- W2967320851 abstract "Tissue biomechanical properties are known to be sensitive to pathological changes. Accordingly, various techniques have been developed to estimate tissue mechanical properties. Shear-wave elastography (SWE) measures shear-wave speed (SWS) in tissues, which can be related to shear modulus. Although viscosity or stress-strain nonlinearity may act as confounder of SWE, their explicit characterization may also provide additional information about tissue composition as a contrast modality. Viscosity can be related to frequency dispersion of SWS, which can be characterized using multi-frequency measurements, herein called spectral SWE (SSWE). Additionally, nonlinear shear modulus can be quantified and parameterized based on SWS changes with respect to applied stress, a phenomenon called acoustoelasticity (AE). In this work, we characterize the nonlinear parameters of tissue as a function of excitation frequency by utilizing both AE and SSWE together. For this, we apply incremental amounts of quasi-static stress on a medium, while imaging and quantifying SWS dispersion via SSWE. Results from phantom and ex vivo porcine liver experiments demonstrate the feasibility of measuring frequency-dependent nonlinear parameters using the proposed method. SWS propagation in porcine liver tissue was observed to change from 1.8 m/s at 100 Hz to 3.3 m/s at 700 Hz, while increasing by approximately 25% from a strain of 0% to 12% across these frequencies." @default.
- W2967320851 created "2019-08-22" @default.
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- W2967320851 date "2019-12-01" @default.
- W2967320851 modified "2023-10-12" @default.
- W2967320851 title "Spectral Quantification of Nonlinear Elasticity Using Acoustoelasticity and Shear-Wave Dispersion" @default.
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- W2967320851 doi "https://doi.org/10.1109/tuffc.2019.2933952" @default.
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