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• W2967331390 endingPage "742" @default.
• W2967331390 startingPage "736" @default.
• W2967331390 abstract "Vaccination therapy using tumour antigen-loaded, autologous dendritic cells (DC) is a promising therapeutic approach alongside standard treatment for glioblastoma (GBM). However, reliable diagnostic criteria regarding therapy monitoring are not established. Here, we analysed the impact of additional 18F-fluoroethyl-tyrosine positron emission tomography (18F-FET PET) imaging following DC vaccination therapy.We analysed data of GBM patients who received DC vaccination therapy. Following MRI diagnosis of tumour recurrence, additional static and dynamic 18F-FET PET imaging was performed. Vaccination was performed five times by intradermal injections, either weekly between concomitant radio/-chemotherapy and intermittent chemotherapy or after tumour recurrence, before re-radiation therapy. MRI and 18F-FET PET results were compared and correlated with clinical data.Between 2003 and 2016, 5 patients were identified who received DC vaccination and 18F-FET PET imaging (1 female/4 males; mean age: 44 ± 14 y). 3/5 patients showed congruent results of tumour progression. In three patients 18F-FET PET indicated treatment related changes, which was in contrast to MRI findings that indicated tumour progression. In these patients 18F-FET PET results could be confirmed by either neuropathological diagnosis or according to the RANO criteria.Despite the small patients number our results indicate an additional impact of 18F-FET PET for monitoring outcome following vaccination therapy." @default.
• W2967331390 created "2019-08-22" @default.
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• W2967331390 date "2019-08-13" @default.
• W2967331390 modified "2023-09-27" @default.
• W2967331390 title "Diagnostic impact of additional O-(2-[18F]fluoroethyl)-L-tyrosine (¹⁸F-FET) PET following immunotherapy with dendritic cell vaccination in glioblastoma patients" @default.
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• W2967331390 doi "https://doi.org/10.1080/02688697.2019.1639615" @default.
• W2967331390 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31407920" @default.
• W2967331390 hasPublicationYear "2019" @default.
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