FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2967357475> ?p ?o ?g. }

• W2967357475 endingPage "111549" @default.
• W2967357475 startingPage "111549" @default.
• W2967357475 abstract "Abstract In this work, we have developed novel multifunctional magnetic-polymeric nanoparticles (MMPNs) based ferrofluids by encapsulating oleylamine (OM)-coated hydrophobic superparamagnetic iron oxide nanoparticles (SPIONs) inside the poly(lactic-co-glycolic acid) (PLGA) nanoparticles (NPs) individually, and along with two drugs such as curcumin (Cur, a chemotherapeutic drug (CHD)), and/or verapamil (Ver, a calcium channel blocker (CCB)). Herein, several parameters such as weighed amount (wt%) of PLGA polymer (i.e., Resomer), stabilizer (i.e., polyvinyl alcohol (PVA)), organic solvents, amount of the SPIONs (in liquid suspension and powder forms), and amount of the drugs (i.e., Cur or/and Ver) are varied during the encapsulation process to optimize the formulation of PLGA NPs. The resulting polymeric NPs including empty PLGA NPs (i.e., without SPIONs/drugs), and MMPNs such as SPIONs-loaded PLGA NPs, Cur-SPIONs-loaded PLGA NPs, Ver-SPIONs-loaded PLGA NPs, and Cur-Ver-SPIONs-loaded PLGA NPs have displayed (i) hydrodynamic diameters and zeta potentials in the range of 280.8–287.3 nm, and −21 to – 26 mV, respectively, and (ii) better encapsulation efficiency for the SPIONs/Cur/Ver. In addition, the MMPNs have exhibited (i) magnetization values in the range of 7.6–9.5 emu/g with superparamagnetic behaviour, (ii) concentration based time-dependent temperature raise up-to 42 °C (minimum therapeutic temperature in magnetic fluid hyperthermia (MFH)/thermotherapy) with heating efficacies i.e., specific absorption rate (SAR) and intrinsic loss power (ILP) values ranging from 7 to 36 W/gFe and 0.1–0.4 nHm2/kg, respectively and (iii) better cytocompatibility. Finally, the SPIONs and dual-drugs (Cur &Ver) co-loaded PLGA NPs have shown enhanced therapeutic efficacy in HepG2 cancer cells via combined therapies (i.e., thermotherapy and chemotherapy), as compared to the individual therapy (i.e., thermotherapy or chemotherapy) using the SPIONs/Cur/Ver loaded PLGA NPs. Thus, the as-prepared SPIONs/dual-drugs co-loaded PLGA NPs (i.e., MMPNs based ferrofluids) are potential therapeutic candidates for multi-modal treatment of cancer in vitro using thermotherapy and chemotherapy." @default.
• W2967357475 created "2019-08-22" @default.
• W2967357475 creator A5015857203 @default.
• W2967357475 creator A5027105629 @default.
• W2967357475 creator A5044875412 @default.
• W2967357475 creator A5054436718 @default.
• W2967357475 creator A5070292215 @default.
• W2967357475 creator A5084992295 @default.
• W2967357475 creator A5086383318 @default.
• W2967357475 creator A5088502371 @default.
• W2967357475 date "2019-11-01" @default.
• W2967357475 modified "2023-10-17" @default.
• W2967357475 title "Multifunctional magnetic-polymeric nanoparticles based ferrofluids for multi-modal in vitro cancer treatment using thermotherapy and chemotherapy" @default.
• W2967357475 cites W1160632617 @default.
• W2967357475 cites W1509144955 @default.
• W2967357475 cites W1841028102 @default.
• W2967357475 cites W1844430498 @default.
• W2967357475 cites W1968035235 @default.
• W2967357475 cites W1973335288 @default.
• W2967357475 cites W1981055785 @default.
• W2967357475 cites W1986607180 @default.
• W2967357475 cites W1990641613 @default.
• W2967357475 cites W1992514031 @default.
• W2967357475 cites W1996717754 @default.
• W2967357475 cites W2002853386 @default.
• W2967357475 cites W2005364830 @default.
• W2967357475 cites W2013072648 @default.
• W2967357475 cites W2016194530 @default.
• W2967357475 cites W2016303028 @default.
• W2967357475 cites W2019185497 @default.
• W2967357475 cites W2020398834 @default.
• W2967357475 cites W2025401801 @default.
• W2967357475 cites W2029129350 @default.
• W2967357475 cites W2032958963 @default.
• W2967357475 cites W2033743851 @default.
• W2967357475 cites W2037771757 @default.
• W2967357475 cites W2037845939 @default.
• W2967357475 cites W2043737434 @default.
• W2967357475 cites W2047988255 @default.
• W2967357475 cites W2051652628 @default.
• W2967357475 cites W2052108324 @default.
• W2967357475 cites W2054728384 @default.
• W2967357475 cites W2059481056 @default.
• W2967357475 cites W2062495745 @default.
• W2967357475 cites W2062705764 @default.
• W2967357475 cites W2070801001 @default.
• W2967357475 cites W2076663214 @default.
• W2967357475 cites W2081010182 @default.
• W2967357475 cites W2082822107 @default.
• W2967357475 cites W2087032263 @default.
• W2967357475 cites W2090846307 @default.
• W2967357475 cites W2093626671 @default.
• W2967357475 cites W2100024324 @default.
• W2967357475 cites W2100372768 @default.
• W2967357475 cites W2102777391 @default.
• W2967357475 cites W2102851109 @default.
• W2967357475 cites W2102981587 @default.
• W2967357475 cites W2112805076 @default.
• W2967357475 cites W2116183504 @default.
• W2967357475 cites W2123118992 @default.
• W2967357475 cites W2132005699 @default.
• W2967357475 cites W2134771494 @default.
• W2967357475 cites W2136633731 @default.
• W2967357475 cites W2147810946 @default.
• W2967357475 cites W2152504641 @default.
• W2967357475 cites W2172902239 @default.
• W2967357475 cites W2237691230 @default.
• W2967357475 cites W2263890128 @default.
• W2967357475 cites W2315916647 @default.
• W2967357475 cites W2319555222 @default.
• W2967357475 cites W2328572470 @default.
• W2967357475 cites W2330416628 @default.
• W2967357475 cites W2405513201 @default.
• W2967357475 cites W2415528931 @default.
• W2967357475 cites W2517837279 @default.
• W2967357475 cites W2528231206 @default.
• W2967357475 cites W2530691642 @default.
• W2967357475 cites W2602858717 @default.
• W2967357475 cites W2625950978 @default.
• W2967357475 cites W2736493891 @default.
• W2967357475 cites W2771514512 @default.
• W2967357475 cites W2780635503 @default.
• W2967357475 cites W2790706620 @default.
• W2967357475 cites W2797663696 @default.
• W2967357475 cites W2900146791 @default.
• W2967357475 cites W2900673035 @default.
• W2967357475 cites W561865641 @default.
• W2967357475 doi "https://doi.org/10.1016/j.molliq.2019.111549" @default.
• W2967357475 hasPublicationYear "2019" @default.
• W2967357475 type Work @default.
• W2967357475 sameAs 2967357475 @default.
• W2967357475 citedByCount "20" @default.
• W2967357475 countsByYear W29673574752020 @default.
• W2967357475 countsByYear W29673574752021 @default.
• W2967357475 countsByYear W29673574752022 @default.
• W2967357475 countsByYear W29673574752023 @default.
• W2967357475 crossrefType "journal-article" @default.
• W2967357475 hasAuthorship W2967357475A5015857203 @default.

• next