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- W2967358655 abstract "The use of microhaplotypes (MHs) for ancestry inference has added to an increasing number of ancestry-informative markers (AIMs) for forensic application that includes autosomal single nucleotide polymorphisms (SNPs) and insertions/deletions (indels). This study compares bi-allelic and tri-allelic SNPs as well as MH markers for their ability to differentiate African, European, South Asian, East Asian, and American population groups from the 1000 Genomes Phase 3 database. A range of well-established metrics were applied to rank each marker according to the population differentiation potential they measured. These comprised: absolute allele frequency differences (δ); Rosenberg's informativeness for (ancestry) assignment (In); the fixation index (FST); and the effective number of alleles (Ae). A panel consisting of all three marker types resulted in the lowest mean divergence per population per individual (MDPI = 2.16%) when selected by In. However, when marker types were not mixed, MHs were the highest performing markers by most metrics (MDPI < 4%) for differentiation between the five continental populations." @default.
- W2967358655 created "2019-08-22" @default.
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- W2967358655 date "2019-11-01" @default.
- W2967358655 modified "2023-10-09" @default.
- W2967358655 title "Performance of ancestry-informative SNP and microhaplotype markers" @default.
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- W2967358655 doi "https://doi.org/10.1016/j.fsigen.2019.102141" @default.
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