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• W2967376260 endingPage "485" @default.
• W2967376260 startingPage "485" @default.
• W2967376260 abstract "Sedentary life style is considered to be an independent risk factor for many disorders, including development of type 2 diabetes, obesity, immune dysfunction, asthma, and neurological or coronary heart disease. Irisin is released from myocytes during physical activity, and acts as a link between muscles and other tissues and organs. This myokine is produced as a result of proteolytic cleavage of FNDC5 protein present in the membrane of myocytes. Secretion of irisin is regulated by N-linked oligosaccharides attached to the protein molecule. The two N-glycan molecules, which constitute a significant part of the irisin glycoprotein, regulate the browning of adipocytes, which is the most important function of irisin. A receptor specific for irisin has still not been discovered. In some tissues irisin probably acts via integrins, which are widely expressed transmembrane receptors. Many studies have confirmed the multifunctional role of irisin and the beneficial effects of this molecule on body homeostasis. Irisin reduces systemic inflammation, maintains the balance between resorption and bone formation, and modulates metabolic processes and the functioning of the nervous system. It suppresses the expression and release of pro-inflammatory cytokines in obese individuals and attenuates inflammation in adipose tissue. The impact of irisin on cancer cell proliferation, migration, and invasion has also been demonstrated in numerous studies, which proves its role in carcinogenesis. Owing to these pleiotropic and beneficial properties, irisin may be a potential option to prevent and treat civilization-related diseases which are, nowadays, considered to be the major health problems in Western societies." @default.
• W2967376260 created "2019-08-22" @default.
• W2967376260 creator A5015508604 @default.
• W2967376260 creator A5055905124 @default.
• W2967376260 creator A5079479850 @default.
• W2967376260 date "2019-08-15" @default.
• W2967376260 modified "2023-10-11" @default.
• W2967376260 title "Irisin as a Multifunctional Protein: Implications for Health and Certain Diseases" @default.
• W2967376260 cites W1182461782 @default.
• W2967376260 cites W1634292063 @default.
• W2967376260 cites W1917580135 @default.
• W2967376260 cites W1963877784 @default.
• W2967376260 cites W1967155265 @default.
• W2967376260 cites W1977485742 @default.
• W2967376260 cites W1984787606 @default.
• W2967376260 cites W1984956709 @default.
• W2967376260 cites W1997779847 @default.
• W2967376260 cites W2006949361 @default.
• W2967376260 cites W2008222514 @default.
• W2967376260 cites W2008675205 @default.
• W2967376260 cites W2008869160 @default.
• W2967376260 cites W2012086801 @default.
• W2967376260 cites W2013063895 @default.
• W2967376260 cites W2014312487 @default.
• W2967376260 cites W2023674811 @default.
• W2967376260 cites W2031799962 @default.
• W2967376260 cites W2033234733 @default.
• W2967376260 cites W2038074003 @default.
• W2967376260 cites W2039065701 @default.
• W2967376260 cites W2042504991 @default.
• W2967376260 cites W2046500896 @default.
• W2967376260 cites W2047057864 @default.
• W2967376260 cites W2055945909 @default.
• W2967376260 cites W2069972139 @default.
• W2967376260 cites W2076633494 @default.
• W2967376260 cites W2077145490 @default.
• W2967376260 cites W2085397620 @default.
• W2967376260 cites W2085804706 @default.
• W2967376260 cites W2086079683 @default.
• W2967376260 cites W2096117135 @default.
• W2967376260 cites W2106383476 @default.
• W2967376260 cites W2109582527 @default.
• W2967376260 cites W2111842746 @default.
• W2967376260 cites W2121921343 @default.
• W2967376260 cites W2122793953 @default.
• W2967376260 cites W2125235152 @default.
• W2967376260 cites W2125510262 @default.
• W2967376260 cites W2129804244 @default.
• W2967376260 cites W2132429770 @default.
• W2967376260 cites W2134630622 @default.
• W2967376260 cites W2141783082 @default.
• W2967376260 cites W2145697808 @default.
• W2967376260 cites W2147515151 @default.
• W2967376260 cites W2153263523 @default.
• W2967376260 cites W2153801847 @default.
• W2967376260 cites W2157199218 @default.
• W2967376260 cites W2179357850 @default.
• W2967376260 cites W2182948109 @default.
• W2967376260 cites W2224943614 @default.
• W2967376260 cites W2229994465 @default.
• W2967376260 cites W2396147980 @default.
• W2967376260 cites W2479341738 @default.
• W2967376260 cites W2491264423 @default.
• W2967376260 cites W2516935338 @default.
• W2967376260 cites W2520515896 @default.
• W2967376260 cites W2544192999 @default.
• W2967376260 cites W2560155445 @default.
• W2967376260 cites W2564436755 @default.
• W2967376260 cites W2582042173 @default.
• W2967376260 cites W2600882296 @default.
• W2967376260 cites W2601150704 @default.
• W2967376260 cites W2605513362 @default.
• W2967376260 cites W2605675711 @default.
• W2967376260 cites W2736679476 @default.
• W2967376260 cites W2737521072 @default.
• W2967376260 cites W2743110890 @default.
• W2967376260 cites W2750597077 @default.
• W2967376260 cites W2752771835 @default.
• W2967376260 cites W2755398419 @default.
• W2967376260 cites W2763977787 @default.
• W2967376260 cites W2765168756 @default.
• W2967376260 cites W2767109934 @default.
• W2967376260 cites W2768402021 @default.
• W2967376260 cites W2769570384 @default.
• W2967376260 cites W2794616308 @default.
• W2967376260 cites W2794683930 @default.
• W2967376260 cites W2794942947 @default.
• W2967376260 cites W2799920618 @default.
• W2967376260 cites W2801023584 @default.
• W2967376260 cites W2801707319 @default.
• W2967376260 cites W2804147087 @default.
• W2967376260 cites W2806095605 @default.
• W2967376260 cites W2808663464 @default.
• W2967376260 cites W2811255015 @default.
• W2967376260 cites W2885299722 @default.
• W2967376260 cites W2891977295 @default.
• W2967376260 cites W2896286698 @default.
• W2967376260 cites W2896323318 @default.

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