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- W2967380968 abstract "The effects of administration of cholinotropic agents (neostigmine, hexamethonium, pilocarpine, atropine, nicotine) on liver tissue after the 5 days period of cooling of rats were compared. The analysis of the conditions inducing lipid peroxidation (LPO), the analysis of the substrate components of the LPO in liver, and the evaluation of the LPO products content in the 5 days period of cold loads were made. The data obtained indicate on the contradirectory effects when pilocarpine and nicotine were administered to animals, as well as after administration of atropine and hexamethonium to animals. There was the similar effects after administration of both pilocarpine and hexamethonium and both nicotine and atropine in conditions of activated LPO assessed by substrate components of LPO in the liver after 5 days cooling. On the basis of these results, a hypothesis of reciprocity between muscarinic and nicotinic cholinoreceptors located on the plasma membrane of hepatocytes in the LPO processes of the liver during the period of cold loads has been formulated." @default.
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- W2967380968 date "2019-08-09" @default.
- W2967380968 modified "2023-09-23" @default.
- W2967380968 title "Cholinergic mechanisms of regulation of free radical oxidation of the liver lipids in cold adaptation in rats" @default.
- W2967380968 doi "https://doi.org/10.17816/rcf17241-48" @default.
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