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- W2967391015 endingPage "3456" @default.
- W2967391015 startingPage "3446" @default.
- W2967391015 abstract "Abstract Trace metals are supplied to chemically‐defined media (CDM) for optimal Chinese hamster ovary (CHO) cell culture performance during the production of monoclonal antibodies and other therapeutic proteins. However, lot‐to‐lot and vendor‐to‐vendor variability in raw materials consequently leads to an imbalance of trace metals that are supplied to CDM. This imbalance can yield detrimental effects rooted in several primary mechanisms and pathways including oxidative stress, apoptosis, lactate accumulation, and unfavorable glycan synthesis. Recent research endeavors involve supplying zinc, copper, and manganese to CDM in excess to further maximize culture productivity and product quality. These treatments significantly impact critical quality attributes and furthermore highlight the degree to which trace metal availability can affect CHO cell culture performance. This review highlights the role of trace metal variability, supplementation, and interplay on key cellular mechanisms responsible for overall culture performance and the production and quality of therapeutic proteins." @default.
- W2967391015 created "2019-08-22" @default.
- W2967391015 creator A5034544810 @default.
- W2967391015 creator A5037888138 @default.
- W2967391015 creator A5089051403 @default.
- W2967391015 date "2019-08-30" @default.
- W2967391015 modified "2023-10-17" @default.
- W2967391015 title "Consequences of trace metal variability and supplementation on Chinese hamster ovary (CHO) cell culture performance: A review of key mechanisms and considerations" @default.
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