FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2967391497> ?p ?o ?g. }

• W2967391497 endingPage "3957" @default.
• W2967391497 startingPage "3957" @default.
• W2967391497 abstract "Hypertension can originate from early-life exposure to oxidative stress. As reported, dimethyl fumarate (DMF) activates nuclear factor erythroid-derived 2-related factor 2 (Nrf2) and protects against oxidative stress damage. We examined whether maternal DMF therapy protects adult offspring against hypertension programmed by prenatal dexamethasone (DEX) and postnatal high-fat (HF) diet exposure. We examined male Sprague Dawley rat offspring at 4 months of age from five groups (n = 11–13/group): control, DEX (0.1mg/kg i.p. from gestational day 16 to 22), HF (D12331 diet from weaning to 16 weeks of age), DEX+HF, and DEX+HF+DMF (50mg/kg/day via gastric gavage for 3 weeks during pregnancy). Maternal DMF therapy prevented male offspring against hypertension programmed by combined DEX and HF exposures. The protective effects of maternal DMF include reduced oxidative stress, decreased plasma asymmetric dimethylarginine (ADMA) levels, downregulated the renin-angiotensin system (i.e. Ren, Agt, Ace, and Agtr1a), increased renal protein levels of certain nutrient-sensing signals, and promoted autophagy. In conclusion, maternal Nrf2 activation by DMF protects male adult offspring against hypertension programmed by combined DEX and HF exposures. Our results cast a new light on the therapeutic potential of targeting Nrf2 signaling pathway as reprogramming strategies to prevent programmed hypertension in children exposed to antenatal corticosteroids and postnatally excessive consumption of fat." @default.
• W2967391497 created "2019-08-22" @default.
• W2967391497 creator A5016188669 @default.
• W2967391497 creator A5016797395 @default.
• W2967391497 creator A5020538411 @default.
• W2967391497 creator A5029527384 @default.
• W2967391497 creator A5043800775 @default.
• W2967391497 creator A5057262597 @default.
• W2967391497 creator A5081155708 @default.
• W2967391497 date "2019-08-14" @default.
• W2967391497 modified "2023-10-16" @default.
• W2967391497 title "Protection of Male Rat Offspring against Hypertension Programmed by Prenatal Dexamethasone Administration and Postnatal High-Fat Diet with the Nrf2 Activator Dimethyl Fumarate during Pregnancy" @default.
• W2967391497 cites W1910450791 @default.
• W2967391497 cites W1968371339 @default.
• W2967391497 cites W1973825375 @default.
• W2967391497 cites W1975164000 @default.
• W2967391497 cites W1987857240 @default.
• W2967391497 cites W2029319331 @default.
• W2967391497 cites W2033546952 @default.
• W2967391497 cites W2036621981 @default.
• W2967391497 cites W2037261682 @default.
• W2967391497 cites W2041781505 @default.
• W2967391497 cites W2047399485 @default.
• W2967391497 cites W2047669470 @default.
• W2967391497 cites W2048594557 @default.
• W2967391497 cites W2055971382 @default.
• W2967391497 cites W2057540814 @default.
• W2967391497 cites W2058314819 @default.
• W2967391497 cites W2066320321 @default.
• W2967391497 cites W2067261577 @default.
• W2967391497 cites W2079439277 @default.
• W2967391497 cites W2100411431 @default.
• W2967391497 cites W2106676982 @default.
• W2967391497 cites W2117185007 @default.
• W2967391497 cites W2147044753 @default.
• W2967391497 cites W2157579468 @default.
• W2967391497 cites W2165425050 @default.
• W2967391497 cites W2169101968 @default.
• W2967391497 cites W2182210298 @default.
• W2967391497 cites W2202661905 @default.
• W2967391497 cites W2217835047 @default.
• W2967391497 cites W2486290941 @default.
• W2967391497 cites W2558843241 @default.
• W2967391497 cites W2593341591 @default.
• W2967391497 cites W2607218714 @default.
• W2967391497 cites W2687200388 @default.
• W2967391497 cites W2753995352 @default.
• W2967391497 cites W2772240339 @default.
• W2967391497 cites W2773072411 @default.
• W2967391497 cites W2779339038 @default.
• W2967391497 cites W2780227486 @default.
• W2967391497 cites W2789427704 @default.
• W2967391497 cites W2800706176 @default.
• W2967391497 cites W2894807585 @default.
• W2967391497 cites W2941112787 @default.
• W2967391497 cites W2957289901 @default.
• W2967391497 cites W4256255843 @default.
• W2967391497 doi "https://doi.org/10.3390/ijms20163957" @default.
• W2967391497 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6719242" @default.
• W2967391497 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31416234" @default.
• W2967391497 hasPublicationYear "2019" @default.
• W2967391497 type Work @default.
• W2967391497 sameAs 2967391497 @default.
• W2967391497 citedByCount "28" @default.
• W2967391497 countsByYear W29673914972020 @default.
• W2967391497 countsByYear W29673914972021 @default.
• W2967391497 countsByYear W29673914972022 @default.
• W2967391497 countsByYear W29673914972023 @default.
• W2967391497 crossrefType "journal-article" @default.
• W2967391497 hasAuthorship W2967391497A5016188669 @default.
• W2967391497 hasAuthorship W2967391497A5016797395 @default.
• W2967391497 hasAuthorship W2967391497A5020538411 @default.
• W2967391497 hasAuthorship W2967391497A5029527384 @default.
• W2967391497 hasAuthorship W2967391497A5043800775 @default.
• W2967391497 hasAuthorship W2967391497A5057262597 @default.
• W2967391497 hasAuthorship W2967391497A5081155708 @default.
• W2967391497 hasBestOaLocation W29673914971 @default.
• W2967391497 hasConcept C112672928 @default.
• W2967391497 hasConcept C126322002 @default.
• W2967391497 hasConcept C134018914 @default.
• W2967391497 hasConcept C185592680 @default.
• W2967391497 hasConcept C2776151105 @default.
• W2967391497 hasConcept C2777468819 @default.
• W2967391497 hasConcept C2779234561 @default.
• W2967391497 hasConcept C2779877776 @default.
• W2967391497 hasConcept C2780401358 @default.
• W2967391497 hasConcept C2780655333 @default.
• W2967391497 hasConcept C46973012 @default.
• W2967391497 hasConcept C515207424 @default.
• W2967391497 hasConcept C54355233 @default.
• W2967391497 hasConcept C55493867 @default.
• W2967391497 hasConcept C71924100 @default.
• W2967391497 hasConcept C86803240 @default.
• W2967391497 hasConceptScore W2967391497C112672928 @default.
• W2967391497 hasConceptScore W2967391497C126322002 @default.
• W2967391497 hasConceptScore W2967391497C134018914 @default.
• W2967391497 hasConceptScore W2967391497C185592680 @default.
• W2967391497 hasConceptScore W2967391497C2776151105 @default.

• next