Matches in SemOpenAlex for { <https://semopenalex.org/work/W2967474472> ?p ?o ?g. }
Showing items 1 to 88 of
88
with 100 items per page.
- W2967474472 endingPage "1469" @default.
- W2967474472 startingPage "1464" @default.
- W2967474472 abstract "OBJECTIVE: Data regarding opioid effects on esophageal function are limited. We previously demonstrated an association between chronic opioid use and esophageal motor dysfunction characterized by esophagogastric junction outflow obstruction, distal esophageal spasm, achalasia type III, and possibly Jackhammer esophagus. Our aim was to characterize the influence of different opioids and doses on esophageal dysfunction. METHODS: Retrospective review of 225 patients prescribed oxycodone, hydrocodone, or tramadol for >3 months, who completed high-resolution manometry from 2012 to 2017. Demographic and manometric data were extracted from a prospectively maintained motility database. Frequency of opioid-induced esophageal dysfunction (OIED, defined as distal esophageal spasm, esophagogastric junction outflow obstruction, achalasia type III, or Jackhammer esophagus on high-resolution manometry, was compared among different opioids. The total 24-hour opioid doses for oxycodone, hydrocodone, and tramadol were converted to a morphine equivalent for dose effect analysis. RESULTS: OIED was present in 24% (55 of 225) of opioid users. OIED was significantly more prevalent with oxycodone or hydrocodone use compared with tramadol (31% vs 28% vs 12%, P = 0.0162), and for oxycodone alone vs oxycodone with acetaminophen (43% vs 21%, P = 0.0482). There was no difference in OIED for patients taking hydrocodone alone vs hydrocodone with acetaminophen. Patients with OIED were taking a higher median 24-hour opioid dose than those without OIED (45 vs 30 mg, P = 0.058). DISCUSSION: OIED is more prevalent in patients taking oxycodone or hydrocodone compared with tramadol. There is greater likelihood of OIED developing with higher doses. Reducing the opioid dose or changing to tramadol may reduce OIED in opioid users." @default.
- W2967474472 created "2019-08-22" @default.
- W2967474472 creator A5020562589 @default.
- W2967474472 creator A5061013636 @default.
- W2967474472 creator A5067663829 @default.
- W2967474472 creator A5080271414 @default.
- W2967474472 creator A5080770439 @default.
- W2967474472 creator A5086017036 @default.
- W2967474472 date "2019-08-13" @default.
- W2967474472 modified "2023-10-16" @default.
- W2967474472 title "Opioid-Induced Esophageal Dysfunction: Differential Effects of Type and Dose" @default.
- W2967474472 cites W1590608023 @default.
- W2967474472 cites W1782609078 @default.
- W2967474472 cites W1968567477 @default.
- W2967474472 cites W1997961158 @default.
- W2967474472 cites W2018817087 @default.
- W2967474472 cites W2022892145 @default.
- W2967474472 cites W2023804350 @default.
- W2967474472 cites W2031668128 @default.
- W2967474472 cites W2050564812 @default.
- W2967474472 cites W2054023539 @default.
- W2967474472 cites W2057243753 @default.
- W2967474472 cites W2066869240 @default.
- W2967474472 cites W2070479673 @default.
- W2967474472 cites W2089611482 @default.
- W2967474472 cites W2093685229 @default.
- W2967474472 cites W2110791210 @default.
- W2967474472 cites W2152354642 @default.
- W2967474472 doi "https://doi.org/10.14309/ajg.0000000000000369" @default.
- W2967474472 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31403963" @default.
- W2967474472 hasPublicationYear "2019" @default.
- W2967474472 type Work @default.
- W2967474472 sameAs 2967474472 @default.
- W2967474472 citedByCount "52" @default.
- W2967474472 countsByYear W29674744722019 @default.
- W2967474472 countsByYear W29674744722020 @default.
- W2967474472 countsByYear W29674744722021 @default.
- W2967474472 countsByYear W29674744722022 @default.
- W2967474472 countsByYear W29674744722023 @default.
- W2967474472 crossrefType "journal-article" @default.
- W2967474472 hasAuthorship W2967474472A5020562589 @default.
- W2967474472 hasAuthorship W2967474472A5061013636 @default.
- W2967474472 hasAuthorship W2967474472A5067663829 @default.
- W2967474472 hasAuthorship W2967474472A5080271414 @default.
- W2967474472 hasAuthorship W2967474472A5080770439 @default.
- W2967474472 hasAuthorship W2967474472A5086017036 @default.
- W2967474472 hasConcept C126322002 @default.
- W2967474472 hasConcept C170493617 @default.
- W2967474472 hasConcept C2776029756 @default.
- W2967474472 hasConcept C2776389719 @default.
- W2967474472 hasConcept C2779777798 @default.
- W2967474472 hasConcept C2780505013 @default.
- W2967474472 hasConcept C2780820201 @default.
- W2967474472 hasConcept C2781063702 @default.
- W2967474472 hasConcept C42219234 @default.
- W2967474472 hasConcept C71924100 @default.
- W2967474472 hasConceptScore W2967474472C126322002 @default.
- W2967474472 hasConceptScore W2967474472C170493617 @default.
- W2967474472 hasConceptScore W2967474472C2776029756 @default.
- W2967474472 hasConceptScore W2967474472C2776389719 @default.
- W2967474472 hasConceptScore W2967474472C2779777798 @default.
- W2967474472 hasConceptScore W2967474472C2780505013 @default.
- W2967474472 hasConceptScore W2967474472C2780820201 @default.
- W2967474472 hasConceptScore W2967474472C2781063702 @default.
- W2967474472 hasConceptScore W2967474472C42219234 @default.
- W2967474472 hasConceptScore W2967474472C71924100 @default.
- W2967474472 hasIssue "9" @default.
- W2967474472 hasLocation W29674744721 @default.
- W2967474472 hasLocation W29674744722 @default.
- W2967474472 hasOpenAccess W2967474472 @default.
- W2967474472 hasPrimaryLocation W29674744721 @default.
- W2967474472 hasRelatedWork W2592597011 @default.
- W2967474472 hasRelatedWork W2912718090 @default.
- W2967474472 hasRelatedWork W2946496104 @default.
- W2967474472 hasRelatedWork W2967474472 @default.
- W2967474472 hasRelatedWork W2994037982 @default.
- W2967474472 hasRelatedWork W3105983924 @default.
- W2967474472 hasRelatedWork W3135455502 @default.
- W2967474472 hasRelatedWork W4280491243 @default.
- W2967474472 hasRelatedWork W4292869770 @default.
- W2967474472 hasRelatedWork W4318933544 @default.
- W2967474472 hasVolume "114" @default.
- W2967474472 isParatext "false" @default.
- W2967474472 isRetracted "false" @default.
- W2967474472 magId "2967474472" @default.
- W2967474472 workType "article" @default.