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- W2967490214 abstract "Background: In the United States, a Black-to-White disparity in age-standardized breast cancer mortality rates emerged in the 1980#8217;s and has widened since then. Methods: To explore this racial disparity, Black-to-White breast cancer rate ratios for mortality (MRRBW), incidence (IRRBW), hazard of breast cancer death (HRRBW), and incidence-based mortality (IBM RRBW) were investigated using data from the NCI#8217;s SEER program (1990- 2004). A statistical model was developed to characterize the IBM RRBW expected if the distribution of cases by estrogen receptor (ER) expression and hazard rates for breast cancer death were equal in Blacks and Whites. Results: During this period, observed mortality rates improved in Blacks and Whites. However, MRRBW was >1.0 and increased over time, while IRRBW was generally 1.0 for both diseases. Equalizing the proportions of ER+ and ER- tumors in Blacks and Whites decreased expected IBM RRBW slightly; however, the racial disparity was essentially eliminated when hazard rates of breast cancer death were matched for ER+ and ER- tumors. Conclusions: Our results suggest that the racial disparity in breast cancer mortality was largely driven by the early excess hazard of breast cancer death among Black women diagnosed with ER+ and ER- tumors. Greater emphasis should be placed on identifying the etiology of these early excess hazards, and developing targeted therapeutic strategies accordingly. Citation Information: In: Proc Am Assoc Cancer Res; 2009 Apr 18-22; Denver, CO. Philadelphia (PA): AACR; 2009. Abstract nr 972." @default.
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- W2967490214 date "2009-05-01" @default.
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- W2967490214 title "Abstract #972: Underlying causes of the Black-White racial disparity in breast cancer mortality: A population-based analysis" @default.
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