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• W2967506598 endingPage "4046" @default.
• W2967506598 startingPage "4046" @default.
• W2967506598 abstract "The aetiology of rheumatoid arthritis (RA) is unknown, but citrullination of proteins is thought to be an initiating event. In addition, it is increasingly evident that the lung can be a potential site for the generation of autoimmune triggers before the development of joint disease. Here, we identified that serum levels of galectin-9 (Gal-9), a pleiotropic immunomodulatory protein, are elevated in RA patients, and are even further increased in patients with comorbid bronchiectasis, a lung disease caused by chronic inflammation. The serum concentrations of Gal-9 correlate with C-reactive protein levels and DAS-28 score. Gal-9 activated polymorphonuclear leukocytes (granulocytes) in vitro, which was characterized by increased cytokine secretion, migration, and survival. Further, granulocytes treated with Gal-9 upregulated expression of peptidyl arginine deiminase 4 (PAD-4), a key enzyme required for RA-associated citrullination of proteins. Correspondingly, treatment with Gal-9 triggered citrullination of intracellular granulocyte proteins that are known contributors to RA pathogenesis (i.e., myeloperoxidase, alpha-enolase, MMP-9, lactoferrin). In conclusion, this study identifies for the first time an immunomodulatory protein, Gal-9, that triggers activation of granulocytes leading to increased PAD-4 expression and generation of citrullinated autoantigens. This pathway may represent a potentially important mechanism for development of RA." @default.
• W2967506598 created "2019-08-22" @default.
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• W2967506598 date "2019-08-19" @default.
• W2967506598 modified "2023-09-26" @default.
• W2967506598 title "Galectin-9 Is a Possible Promoter of Immunopathology in Rheumatoid Arthritis by Activation of Peptidyl Arginine Deiminase 4 (PAD-4) in Granulocytes" @default.
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• W2967506598 cites W1605753053 @default.
• W2967506598 cites W1638726768 @default.
• W2967506598 cites W1754972901 @default.
• W2967506598 cites W1790082869 @default.
• W2967506598 cites W1832022780 @default.
• W2967506598 cites W1837900189 @default.
• W2967506598 cites W1899509990 @default.
• W2967506598 cites W1903306669 @default.
• W2967506598 cites W1966193262 @default.
• W2967506598 cites W1966194999 @default.
• W2967506598 cites W1972948730 @default.
• W2967506598 cites W1974015269 @default.
• W2967506598 cites W1976800458 @default.
• W2967506598 cites W1977099149 @default.
• W2967506598 cites W1983206076 @default.
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• W2967506598 cites W1986072506 @default.
• W2967506598 cites W1988468169 @default.
• W2967506598 cites W1992873661 @default.
• W2967506598 cites W1994299552 @default.
• W2967506598 cites W1995189450 @default.
• W2967506598 cites W2004350933 @default.
• W2967506598 cites W2005121187 @default.
• W2967506598 cites W2013088656 @default.
• W2967506598 cites W2013573826 @default.
• W2967506598 cites W2033753616 @default.
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• W2967506598 cites W2040992929 @default.
• W2967506598 cites W2046265974 @default.
• W2967506598 cites W2050286820 @default.
• W2967506598 cites W2053608295 @default.
• W2967506598 cites W2058380315 @default.
• W2967506598 cites W2063459223 @default.
• W2967506598 cites W2070631889 @default.
• W2967506598 cites W2074721716 @default.
• W2967506598 cites W2087798242 @default.
• W2967506598 cites W2088373848 @default.
• W2967506598 cites W2104669609 @default.
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• W2967506598 cites W2105384918 @default.
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• W2967506598 cites W2135655382 @default.
• W2967506598 cites W2136131602 @default.
• W2967506598 cites W2136383251 @default.
• W2967506598 cites W2141342904 @default.
• W2967506598 cites W2141522272 @default.
• W2967506598 cites W2155712838 @default.
• W2967506598 cites W2158236406 @default.
• W2967506598 cites W2166273165 @default.
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• W2967506598 doi "https://doi.org/10.3390/ijms20164046" @default.
• W2967506598 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6721145" @default.
• W2967506598 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31430907" @default.
• W2967506598 hasPublicationYear "2019" @default.
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