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- W2967551210 abstract "Abstract An efficient palladium‐catalyzed tandem addition/cyclization of 2′‐formyl‐[1,1′‐biaryl]‐2‐carbonitriles with arylboronic acids is reported. This reaction affords dibenzo[ c , e ]azepin‐5‐ols and benzo[ c ]pyrido[2,3‐ e ]azepin‐5‐ols with excellent selectivity and wide functional group compatibility. The dibenzo[ c , e ]azepin‐5‐ols show good cell growth inhibitory activity against a triple‐negative breast cancer cell line. Moreover, the proposed mechanistic rationale for this tandem process is supported by theoretical calculations. magnified image" @default.
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- W2967551210 date "2019-08-27" @default.
- W2967551210 modified "2023-10-16" @default.
- W2967551210 title "Palladium‐Catalyzed Selective Synthesis of Dibenzo[ <i>c</i> , <i>e</i> ]azepin‐5‐ols and Benzo[ <i>c</i> ]pyrido[2,3‐ <i>e</i> ]azepin‐5‐ols" @default.
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- W2967551210 doi "https://doi.org/10.1002/adsc.201900705" @default.
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