FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2967620211> ?p ?o ?g. }

• W2967620211 endingPage "15004" @default.
• W2967620211 startingPage "15000" @default.
• W2967620211 abstract "The development of a fluorescent LCK inhibitor that exhibits favourable solvatochromic properties upon binding the kinase is described. Fluorescent properties were realised through the inclusion of a prodan-derived fluorophore into the pharmacophore of an ATP-competitive kinase inhibitor. Fluorescence titration experiments demonstrate the solvatochromic properties of the inhibitor, in which dramatic increase in emission intensity and hypsochromic shift in emission maxima are clearly observed upon binding LCK. Microscopy experiments in cellular contexts together with flow cytometry show that the fluorescence intensity of the inhibitor correlates with the LCK concentration. Furthermore, multiphoton microscopy experiments demonstrate both the rapid cellular uptake of the inhibitor and that the two-photon cross section of the inhibitor is amenable for excitation at 700 nm." @default.
• W2967620211 created "2019-08-22" @default.
• W2967620211 creator A5001411573 @default.
• W2967620211 creator A5006463638 @default.
• W2967620211 creator A5035703153 @default.
• W2967620211 creator A5042539600 @default.
• W2967620211 creator A5067041403 @default.
• W2967620211 creator A5091395541 @default.
• W2967620211 date "2019-09-05" @default.
• W2967620211 modified "2023-10-15" @default.
• W2967620211 title "A Fluorescent Kinase Inhibitor that Exhibits Diagnostic Changes in Emission upon Binding" @default.
• W2967620211 cites W1500018432 @default.
• W2967620211 cites W1972577475 @default.
• W2967620211 cites W1975178023 @default.
• W2967620211 cites W1993212989 @default.
• W2967620211 cites W1994673901 @default.
• W2967620211 cites W2005942279 @default.
• W2967620211 cites W2013829463 @default.
• W2967620211 cites W2017279988 @default.
• W2967620211 cites W2018001535 @default.
• W2967620211 cites W2020279663 @default.
• W2967620211 cites W2026907550 @default.
• W2967620211 cites W2032012867 @default.
• W2967620211 cites W2039090007 @default.
• W2967620211 cites W2092680120 @default.
• W2967620211 cites W2102013854 @default.
• W2967620211 cites W2103445331 @default.
• W2967620211 cites W2107985655 @default.
• W2967620211 cites W2108198962 @default.
• W2967620211 cites W2136284171 @default.
• W2967620211 cites W2136795628 @default.
• W2967620211 cites W2141634655 @default.
• W2967620211 cites W2316157743 @default.
• W2967620211 cites W2394994671 @default.
• W2967620211 cites W2568046654 @default.
• W2967620211 cites W2756470837 @default.
• W2967620211 cites W2758964647 @default.
• W2967620211 cites W2763434265 @default.
• W2967620211 cites W2794211762 @default.
• W2967620211 cites W58180742 @default.
• W2967620211 cites W2322059529 @default.
• W2967620211 doi "https://doi.org/10.1002/anie.201909536" @default.
• W2967620211 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6851755" @default.
• W2967620211 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31411364" @default.
• W2967620211 hasPublicationYear "2019" @default.
• W2967620211 type Work @default.
• W2967620211 sameAs 2967620211 @default.
• W2967620211 citedByCount "9" @default.
• W2967620211 countsByYear W29676202112020 @default.
• W2967620211 countsByYear W29676202112021 @default.
• W2967620211 countsByYear W29676202112023 @default.
• W2967620211 crossrefType "journal-article" @default.
• W2967620211 hasAuthorship W2967620211A5001411573 @default.
• W2967620211 hasAuthorship W2967620211A5006463638 @default.
• W2967620211 hasAuthorship W2967620211A5035703153 @default.
• W2967620211 hasAuthorship W2967620211A5042539600 @default.
• W2967620211 hasAuthorship W2967620211A5067041403 @default.
• W2967620211 hasAuthorship W2967620211A5091395541 @default.
• W2967620211 hasBestOaLocation W29676202111 @default.
• W2967620211 hasConcept C120665830 @default.
• W2967620211 hasConcept C121332964 @default.
• W2967620211 hasConcept C12554922 @default.
• W2967620211 hasConcept C17814232 @default.
• W2967620211 hasConcept C185592680 @default.
• W2967620211 hasConcept C2778617687 @default.
• W2967620211 hasConcept C67218372 @default.
• W2967620211 hasConcept C75473681 @default.
• W2967620211 hasConcept C86803240 @default.
• W2967620211 hasConcept C91881484 @default.
• W2967620211 hasConceptScore W2967620211C120665830 @default.
• W2967620211 hasConceptScore W2967620211C121332964 @default.
• W2967620211 hasConceptScore W2967620211C12554922 @default.
• W2967620211 hasConceptScore W2967620211C17814232 @default.
• W2967620211 hasConceptScore W2967620211C185592680 @default.
• W2967620211 hasConceptScore W2967620211C2778617687 @default.
• W2967620211 hasConceptScore W2967620211C67218372 @default.
• W2967620211 hasConceptScore W2967620211C75473681 @default.
• W2967620211 hasConceptScore W2967620211C86803240 @default.
• W2967620211 hasConceptScore W2967620211C91881484 @default.
• W2967620211 hasFunder F4320322581 @default.
• W2967620211 hasFunder F4320332999 @default.
• W2967620211 hasIssue "42" @default.
• W2967620211 hasLocation W29676202111 @default.
• W2967620211 hasLocation W29676202112 @default.
• W2967620211 hasLocation W29676202113 @default.
• W2967620211 hasLocation W29676202114 @default.
• W2967620211 hasLocation W29676202115 @default.
• W2967620211 hasOpenAccess W2967620211 @default.
• W2967620211 hasPrimaryLocation W29676202111 @default.
• W2967620211 hasRelatedWork W1847253029 @default.
• W2967620211 hasRelatedWork W1973488035 @default.
• W2967620211 hasRelatedWork W2022040498 @default.
• W2967620211 hasRelatedWork W2030037688 @default.
• W2967620211 hasRelatedWork W2046419808 @default.
• W2967620211 hasRelatedWork W2063280272 @default.
• W2967620211 hasRelatedWork W2157573986 @default.
• W2967620211 hasRelatedWork W2612671941 @default.
• W2967620211 hasRelatedWork W2900569474 @default.

• next