FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2967624601> ?p ?o ?g. }

• W2967624601 endingPage "3927" @default.
• W2967624601 startingPage "3927" @default.
• W2967624601 abstract "One of the main obstacles to the effective treatment of ovarian cancer patients continues to be the drug resistance of cancer cells. Osteoblast-Specific Factor 2 (OSF-2, Periostin) is a secreted extracellular matrix protein (ECM) expressed in fibroblasts during bone and teeth development. Expression of OSF-2 has been also related to the progression and drug resistance of different tumors. The present study investigated the role of OSF-2 by evaluating its expression in the primary serous ovarian cancer cell line, sensitive (W1) and resistant to doxorubicin (DOX) (W1DR) and methotrexate (MTX) (W1MR). The OSF-2 transcript (real-time PCR analysis), protein expression in cell lysates and cell culture medium (western blot), and expression of the OSF-2 protein in cell lines (immunofluorescence) were investigated in this study. Increased expression of OSF-2 mRNA was observed in drug-resistant cells and followed by increased protein expression in cell culture media of drug-resistant cell lines. A subpopulation of ALDH1A1-positive cells was noted for W1DR and W1MR cell lines; however, no direct co-expression with OSF-2 was demonstrated. Both drugs induced OSF-2 expression after a short period of exposure of the drug-sensitive cell line to DOX and MTX. The obtained results indicate that OSF-2 expression might be associated with the development of DOX and MTX resistance in the primary serous W1 ovarian cancer cell line." @default.
• W2967624601 created "2019-08-22" @default.
• W2967624601 creator A5022944139 @default.
• W2967624601 creator A5025909781 @default.
• W2967624601 creator A5079063862 @default.
• W2967624601 creator A5081102916 @default.
• W2967624601 creator A5086588218 @default.
• W2967624601 creator A5088287145 @default.
• W2967624601 creator A5089180685 @default.
• W2967624601 creator A5089946307 @default.
• W2967624601 date "2019-08-13" @default.
• W2967624601 modified "2023-10-18" @default.
• W2967624601 title "Expression of Osteoblast-Specific Factor 2 (OSF-2, Periostin) Is Associated with Drug Resistance in Ovarian Cancer Cell Lines" @default.
• W2967624601 cites W1529267387 @default.
• W2967624601 cites W1956445694 @default.
• W2967624601 cites W1958921890 @default.
• W2967624601 cites W1966880532 @default.
• W2967624601 cites W1981782394 @default.
• W2967624601 cites W1984556500 @default.
• W2967624601 cites W1990575167 @default.
• W2967624601 cites W1996474536 @default.
• W2967624601 cites W2002659318 @default.
• W2967624601 cites W2002906517 @default.
• W2967624601 cites W2005801434 @default.
• W2967624601 cites W2017975901 @default.
• W2967624601 cites W2020131167 @default.
• W2967624601 cites W2025683553 @default.
• W2967624601 cites W2026862874 @default.
• W2967624601 cites W2028904725 @default.
• W2967624601 cites W2032879513 @default.
• W2967624601 cites W2035371717 @default.
• W2967624601 cites W2041125186 @default.
• W2967624601 cites W2049264404 @default.
• W2967624601 cites W2051890222 @default.
• W2967624601 cites W2056772956 @default.
• W2967624601 cites W2057988845 @default.
• W2967624601 cites W2058073053 @default.
• W2967624601 cites W2061582963 @default.
• W2967624601 cites W2065949950 @default.
• W2967624601 cites W2066414300 @default.
• W2967624601 cites W2070901986 @default.
• W2967624601 cites W2094488761 @default.
• W2967624601 cites W2107457010 @default.
• W2967624601 cites W2110263673 @default.
• W2967624601 cites W2114150480 @default.
• W2967624601 cites W2122616632 @default.
• W2967624601 cites W2122920182 @default.
• W2967624601 cites W2131487381 @default.
• W2967624601 cites W2141295465 @default.
• W2967624601 cites W2145180727 @default.
• W2967624601 cites W2154271021 @default.
• W2967624601 cites W2154613259 @default.
• W2967624601 cites W2166657167 @default.
• W2967624601 cites W2256172715 @default.
• W2967624601 cites W2475148876 @default.
• W2967624601 cites W2480701760 @default.
• W2967624601 cites W2606990581 @default.
• W2967624601 cites W2738462696 @default.
• W2967624601 cites W2744855162 @default.
• W2967624601 cites W2754439280 @default.
• W2967624601 cites W2764211476 @default.
• W2967624601 cites W2765091867 @default.
• W2967624601 cites W2797536126 @default.
• W2967624601 cites W2891223802 @default.
• W2967624601 cites W2898868991 @default.
• W2967624601 cites W2899159263 @default.
• W2967624601 cites W2902854367 @default.
• W2967624601 cites W2906274651 @default.
• W2967624601 cites W4211147776 @default.
• W2967624601 cites W4236530034 @default.
• W2967624601 cites W4243218074 @default.
• W2967624601 doi "https://doi.org/10.3390/ijms20163927" @default.
• W2967624601 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6719218" @default.
• W2967624601 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31412536" @default.
• W2967624601 hasPublicationYear "2019" @default.
• W2967624601 type Work @default.
• W2967624601 sameAs 2967624601 @default.
• W2967624601 citedByCount "12" @default.
• W2967624601 countsByYear W29676246012019 @default.
• W2967624601 countsByYear W29676246012020 @default.
• W2967624601 countsByYear W29676246012021 @default.
• W2967624601 countsByYear W29676246012022 @default.
• W2967624601 countsByYear W29676246012023 @default.
• W2967624601 crossrefType "journal-article" @default.
• W2967624601 hasAuthorship W2967624601A5022944139 @default.
• W2967624601 hasAuthorship W2967624601A5025909781 @default.
• W2967624601 hasAuthorship W2967624601A5079063862 @default.
• W2967624601 hasAuthorship W2967624601A5081102916 @default.
• W2967624601 hasAuthorship W2967624601A5086588218 @default.
• W2967624601 hasAuthorship W2967624601A5088287145 @default.
• W2967624601 hasAuthorship W2967624601A5089180685 @default.
• W2967624601 hasAuthorship W2967624601A5089946307 @default.
• W2967624601 hasBestOaLocation W29676246011 @default.
• W2967624601 hasConcept C121608353 @default.
• W2967624601 hasConcept C126322002 @default.
• W2967624601 hasConcept C153911025 @default.
• W2967624601 hasConcept C189165786 @default.
• W2967624601 hasConcept C2777699602 @default.

• next