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• W2967654848 abstract "Introduction Increased salt taste sensitivity may be associated with improved heart failure (HF) outcomes following HF hospitalization. Hypothesis An increase in salt taste sensitivity from admission to 12-weeks follow-up will be associated with fewer days rehospitalized and higher Kansas City Cardiomyopathy Questionnaire clinical summary scores (KCCQ-CSS) compared to subjects with no increase in salt taste sensitivity. Methods We examined salt taste sensitivity in the GOURMET-HF trial, a pilot study investigating the effects of home-delivered meals in post-discharge patients with HF. Salt taste sensitivity was assessed by measuring changes in salt taste recognition threshold on enrollment, discharge, 1, 4, and 12-weeks follow-up using Salsave test strips standardized with 0.6-1.6 mg/cm2 NaCl solution. Subjects were divided into two groups: increase or no increase salt taste sensitivity. Baseline characteristics between groups and outcomes were compared using two-sample t-tests, chi-squared tests, and log-transformed t-tests for parameters that were not normally distributed. Results Baseline characteristics did not differ for subjects with an increase in salt taste sensitivity over 12-weeks (n=25) compared to those without an increase in salt taste sensitivity (n=24); they were elderly (71 vs. 69 years) and predominately male (76 vs. 75%). There was a high representation of black (36 vs. 29%) and Hispanic (28 vs. 42%) subjects. Baseline KCCQ-CSS (45.84 [21.74] vs. 44.31 [17.70]) were similar. The enrollment salt taste recognition threshold was higher (1.19 [0.39]) vs. 0.76 [0.28] mg/cm2, p=0.001) and the 12-week threshold was lower (0.71 [0.16] vs. 0.86 [0.32] mg/cm2, p=0.042) in the group with increased salt taste sensitivity. The total number 12-week hospital days was 60 vs. 121 days, with an average number of hospital days of 5.45 [3.88] vs. 11.00 [6.74] (p=0.028) among those hospitalized in the groups with an increase vs. no increase in salt taste sensitivity, respectively (Figure 1). KCCQ-CSS at 12-weeks trended higher in the group with an increase in salt taste sensitivity: (64.24 [23.06] vs. 56.25 [24.80], p=0.195). Conclusions Changes in salt taste sensitivity occurred in some but not all subjects in a 12-week period following hospitalization for HF. Subjects with increased salt taste sensitivity over this time period were rehospitalized for fewer days. Improved salt taste sensitivity may represent a novel prognostic factor in post-discharge patients with HF." @default.
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• W2967654848 date "2019-08-01" @default.
• W2967654848 modified "2023-10-17" @default.
• W2967654848 title "Changes in Salt Taste Sensitivity and Heart Failure Readmissions" @default.
• W2967654848 doi "https://doi.org/10.1016/j.cardfail.2019.07.085" @default.
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