Matches in SemOpenAlex for { <https://semopenalex.org/work/W2967673177> ?p ?o ?g. }
- W2967673177 abstract "Envelope glycoprotein (Env) spikes on the surface of human immunodeficiency virus (HIV-1) bind target cell receptors, triggering changes in the shape of Env. We studied a small molecule, MF275, that also induced shape changes in Env. The consequences of MF275 interaction with Env depended on the HIV-1 strain, with infection by some viruses inhibited and infection by other viruses enhanced. These studies reveal the strain-dependent diversity of HIV-1 Envs as they undergo shape changes in proceeding down the entry pathway. Appreciation of this diversity will assist attempts to develop broadly active inhibitors of HIV-1 entry." @default.
- W2967673177 created "2019-08-22" @default.
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- W2967673177 date "2019-11-01" @default.
- W2967673177 modified "2023-10-16" @default.
- W2967673177 title "Strain-Dependent Activation and Inhibition of Human Immunodeficiency Virus Entry by a Specific PF-68742 Stereoisomer" @default.
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