Matches in SemOpenAlex for { <https://semopenalex.org/work/W2967685953> ?p ?o ?g. }
- W2967685953 startingPage "242941" @default.
- W2967685953 abstract "Abstract Post-prandial blood glucose is cleared by insulin-mediated release of Glucose Transporter 4 (GLUT4) from an intracellular GLUT4 storage compartment (GSC) to the surface of muscle and adipose tissue. Here we map the biosynthetic pathway for human GSC formation, which involves the clathrin isoform CHC22. We observe that GLUT4 transits more slowly through the early secretory pathway than the constitutively secreted GLUT1 transporter, and show CHC22 colocalizes with p115 in the endoplasmic-reticulum-to-Golgi-intermediate compartment (ERGIC). We find CHC22 mediates membrane traffic from the early secretory pathway during formation of Legionella pneumophila’s replication vacuole, which also acquires components of the GLUT4 pathway. We show that p115 but not GM130 is required for GSC formation from the ERGIC, indicating Golgi bypass. This GSC biogenesis pathway is attenuated in mice, which lack CHC22 and rely mainly on recapture of surface GLUT4 to populate their GSC. In humans, GLUT4 traffic to the GSC is enhanced by CHC22 at the ERGIC, which has implications for pathways to insulin resistance. Summary Blood glucose clearance relies on insulin-mediated exocytosis of glucose transporter 4 (GLUT4) from the GLUT4 storage compartment (GSC). Pathways to GSC formation are unknown. We show that CHC22 clathrin mediates GSC biogenesis from the ER-to-Golgi Intermediate Compartment in humans." @default.
- W2967685953 created "2019-08-22" @default.
- W2967685953 creator A5005487615 @default.
- W2967685953 creator A5024354377 @default.
- W2967685953 creator A5026896911 @default.
- W2967685953 creator A5028720131 @default.
- W2967685953 creator A5030196766 @default.
- W2967685953 creator A5030255436 @default.
- W2967685953 creator A5030757228 @default.
- W2967685953 creator A5033940715 @default.
- W2967685953 creator A5045189680 @default.
- W2967685953 creator A5072897813 @default.
- W2967685953 creator A5084806589 @default.
- W2967685953 creator A5086047033 @default.
- W2967685953 date "2018-12-17" @default.
- W2967685953 modified "2023-09-25" @default.
- W2967685953 title "CHC22 clathrin initiates biogenesis of the human GLUT4 storage compartment from the early secretory pathway" @default.
- W2967685953 cites W1940760798 @default.
- W2967685953 cites W1965499150 @default.
- W2967685953 cites W1967701730 @default.
- W2967685953 cites W1975964692 @default.
- W2967685953 cites W1981594750 @default.
- W2967685953 cites W1981940952 @default.
- W2967685953 cites W1991410135 @default.
- W2967685953 cites W1996107769 @default.
- W2967685953 cites W1997957892 @default.
- W2967685953 cites W2002018183 @default.
- W2967685953 cites W2003861253 @default.
- W2967685953 cites W2005527680 @default.
- W2967685953 cites W2005753856 @default.
- W2967685953 cites W2010378383 @default.
- W2967685953 cites W2011599911 @default.
- W2967685953 cites W2011747741 @default.
- W2967685953 cites W2023581910 @default.
- W2967685953 cites W2026904918 @default.
- W2967685953 cites W2038081709 @default.
- W2967685953 cites W2042917756 @default.
- W2967685953 cites W2048251935 @default.
- W2967685953 cites W2051083711 @default.
- W2967685953 cites W2051399235 @default.
- W2967685953 cites W2052308537 @default.
- W2967685953 cites W2061849844 @default.
- W2967685953 cites W2061990118 @default.
- W2967685953 cites W2066240922 @default.
- W2967685953 cites W2068891266 @default.
- W2967685953 cites W2070992410 @default.
- W2967685953 cites W2080742233 @default.
- W2967685953 cites W2082825744 @default.
- W2967685953 cites W2085389244 @default.
- W2967685953 cites W2091591759 @default.
- W2967685953 cites W2094663320 @default.
- W2967685953 cites W2095381111 @default.
- W2967685953 cites W2096466814 @default.
- W2967685953 cites W2109223015 @default.
- W2967685953 cites W2113980459 @default.
- W2967685953 cites W2118130192 @default.
- W2967685953 cites W2118702694 @default.
- W2967685953 cites W2119441048 @default.
- W2967685953 cites W2119575179 @default.
- W2967685953 cites W2127767424 @default.
- W2967685953 cites W2130965044 @default.
- W2967685953 cites W2133244586 @default.
- W2967685953 cites W2136036129 @default.
- W2967685953 cites W2136755280 @default.
- W2967685953 cites W2139059560 @default.
- W2967685953 cites W2140692553 @default.
- W2967685953 cites W2142336398 @default.
- W2967685953 cites W2145164437 @default.
- W2967685953 cites W2152089340 @default.
- W2967685953 cites W2154597181 @default.
- W2967685953 cites W2155802517 @default.
- W2967685953 cites W2160300109 @default.
- W2967685953 cites W2166249172 @default.
- W2967685953 cites W2169182626 @default.
- W2967685953 cites W2222323516 @default.
- W2967685953 cites W2233026563 @default.
- W2967685953 cites W2328548905 @default.
- W2967685953 cites W2407806699 @default.
- W2967685953 cites W2408822320 @default.
- W2967685953 cites W2471596662 @default.
- W2967685953 cites W2567789553 @default.
- W2967685953 cites W26034423 @default.
- W2967685953 cites W2766545511 @default.
- W2967685953 cites W2790506155 @default.
- W2967685953 cites W990212049 @default.
- W2967685953 hasPublicationYear "2018" @default.
- W2967685953 type Work @default.
- W2967685953 sameAs 2967685953 @default.
- W2967685953 citedByCount "0" @default.
- W2967685953 crossrefType "posted-content" @default.
- W2967685953 hasAuthorship W2967685953A5005487615 @default.
- W2967685953 hasAuthorship W2967685953A5024354377 @default.
- W2967685953 hasAuthorship W2967685953A5026896911 @default.
- W2967685953 hasAuthorship W2967685953A5028720131 @default.
- W2967685953 hasAuthorship W2967685953A5030196766 @default.
- W2967685953 hasAuthorship W2967685953A5030255436 @default.
- W2967685953 hasAuthorship W2967685953A5030757228 @default.
- W2967685953 hasAuthorship W2967685953A5033940715 @default.
- W2967685953 hasAuthorship W2967685953A5045189680 @default.