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- W2967687652 endingPage "104594" @default.
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- W2967687652 abstract "In this study, irbesartan (IST) microparticles, an IST /hydroxypropyl-β-cyclodextrin (HP-β-CD) inclusion complex, and an IST/polyvinylpyrrolidone (PVP) complex were prepared using a supercritical aerosol solvent extraction system (ASES). The goal was to improve the solubility and dissolution rate of IST, which is an angiotensin II receptor blocker and exhibits solubility-limited oral bioavailability in pharmacokinetics. It is noteworthy that these three drug delivery systems show a higher solubility and dissolution rate of IST compared with raw IST. Fourier-transform infrared spectroscopy, differential scanning calorimetry, X-ray diffraction, and scanning electron microscopy analyses were conducted to study the physicochemical properties of IST before and after ASES processing, and to confirm the formation of the IST complexes with HP-β-CD and PVP. This study provides valuable information for the potential clinical application of IST microparticles and IST composite particles synthesized using the ASES process." @default.
- W2967687652 created "2019-08-22" @default.
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- W2967687652 date "2019-11-01" @default.
- W2967687652 modified "2023-09-27" @default.
- W2967687652 title "Preparation of irbesartan composite microparticles by supercritical aerosol solvent extraction system for dissolution enhancement" @default.
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- W2967687652 doi "https://doi.org/10.1016/j.supflu.2019.104594" @default.
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